Structure of PDB 6w6v Chain J Binding Site BS01

Receptor Information
>6w6v Chain J (length=293) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MLVDLNVPWPQNSYADKVTSQAVNNLIKTLSTLHMLGYTHIAINFTVNHS
EKFPNDVKLLNPIDIKRRFGELMDRTGLKLYSRITLIIDDPSKGQSLSKI
SQAFDIVAALPISEKGLTLSTTNLDIDLLTFQYGSRLPTFLKHKSICSCV
NRGVKLEIVYGYALRDVQARRQFVSNVRSVIRSSRSRGIVIGSGAMSPLE
CRNILGVTSLIKNLGLPSDRCSKAMGDLASLVLLNGRLRNKSHKQTIVTG
GGSGNGDDVVNDVQGIDDVQTIKVVKRSMDAEQLGHASKRHKP
Ligand information
>6w6v Chain A (length=294) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
auccaugaccaaagaaucgucacaaaucgaagcuuacaaaauggaguaaa
auuuuacucaguaauaugcuuuggguugaaagucucccaccaauucguau
gcggaaaacguaaugagauuuaaaaauaaaucaacucauuaaggaggaug
ccgguauucugcuucuugaccugguaccucuaggguacugguguucggua
cuggauuccgauggaaucuaaaccauaguuaugacgauugcucuuuccug
gaucgaguaacccaauggagcuuacuauucuugguccauggauu
<<<<<<<<<<<<<.<<<<<<<......<<<<<<..........<<<<<<<
..>>>>>>>........>>>>>>{......[[.((((.<<<.........
<<<.....>>><<<<<<.................>>>>>>.<<.<<<<<<
<<>>>>>>>>.>>.......<<<<<<<<.<<>>>>>>>>>>.....>>>.
..<<<<<<<...>>>>>>>.............>>>>>>><<<<..<<<.>
>>..>>>>...}....))))]]...>....>>>>>>.>>>>>>.
Receptor-Ligand Complex Structure
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PDB6w6v Cryo-EM structure of catalytic ribonucleoprotein complex RNase MRP.
Resolution3.0 Å
Binding residue
(original residue number in PDB)		R185 R187 K223
Binding residue
(residue number reindexed from 1)		R185 R187 K223
Enzymatic activity
Enzyme Commision number 3.1.26.5: ribonuclease P.
Gene Ontology
Molecular Function
GO:0000171 ribonuclease MRP activity
GO:0003723 RNA binding
GO:0004526 ribonuclease P activity
GO:0005515 protein binding
GO:0016787 hydrolase activity
Biological Process
GO:0000294 nuclear-transcribed mRNA catabolic process, RNase MRP-dependent
GO:0000460 maturation of 5.8S rRNA
GO:0001682 tRNA 5'-leader removal
GO:0006364 rRNA processing
GO:0008033 tRNA processing
GO:0034965 intronic box C/D snoRNA processing
Cellular Component
GO:0000172 ribonuclease MRP complex
GO:0005634 nucleus
GO:0005655 nucleolar ribonuclease P complex
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6w6v, PDBe:6w6v, PDBj:6w6v
PDBsum6w6v
PubMed32651392
UniProtP38786|RPP1_YEAST Ribonuclease P/MRP protein subunit RPP1 (Gene Name=RPP1)

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