Structure of PDB 6tm5 Chain J Binding Site BS01

Receptor Information
>6tm5 Chain J (length=504) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NLERLRKRVRQYLDQQQYQSALFWADKVASLSREEPQDIYWLAQCLYLTA
QYHRAAHALRSRKLDKLYEACRYLAARCHYAAKEHQQALDVLDMSQSSIK
SSICLLRGKIYDALDNRTLATYSYKEALKLDVYCFEAFDLLTSHHMLTAQ
EEKELLESLPLSKLCNEEQELLRFLFENKLKKYNKPSETVIPESVDGLQE
NLDVVVSLAERHYYNCDFKMCYKLTSVVMEKDPFHASCLPVHIGTLVELN
KANELFYLSHKLVDLYPSNPVSWFAVGCYYLMVGHKNEHARRYLSKATTL
EKTYGPAWIAYGHSFAVESEHDQAMAAYFTAAQLMKGCHLPMLYIGLEYG
LTNNSKLAERFFSQALSIAPEDPFVMHEVGVVAFQNGEWKTAEKWFLDAL
EKIKAIGNEVTVDKWEPLLNNLGHVCRKLKKYAEALDYHRQALVLIPQNA
STYSAIGYIHSLMGNFENAVDYFHTALGLRRDDTFSVTMLGHCIEMYIGD
SEAY
Ligand information
>6tm5 Chain G (length=25) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
MLRRKPTRLELKLDDIEEFENIRKD
Receptor-Ligand Complex Structure
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PDB6tm5 A unique binding mode of Nek2A to the APC/C allows its ubiquitination during prometaphase.
Resolution3.9 Å
Binding residue
(original residue number in PDB)		Y243 C245 V276 I338 H342 A345 L369 Y373 F403 H406 E407 K443 W444 P446 N449 N450 H453 R456 K457 Y487 F514 M518 H521 M525
Binding residue
(residue number reindexed from 1)		Y214 C216 V247 I309 H313 A316 L340 Y344 F374 H377 E378 K414 W415 P417 N420 N421 H424 R427 K428 Y458 F485 M489 H492 M496
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005515 protein binding
Biological Process
GO:0007346 regulation of mitotic cell cycle
GO:0016567 protein ubiquitination
GO:0031145 anaphase-promoting complex-dependent catabolic process
GO:0045842 positive regulation of mitotic metaphase/anaphase transition
GO:0051301 cell division
GO:0051445 regulation of meiotic cell cycle
GO:0070936 protein K48-linked ubiquitination
GO:0070979 protein K11-linked ubiquitination
GO:0141198 protein branched polyubiquitination
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005680 anaphase-promoting complex
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005819 spindle
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0072686 mitotic spindle

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6tm5, PDBe:6tm5, PDBj:6tm5
PDBsum6tm5
PubMed32307883
UniProtQ13042|CDC16_HUMAN Cell division cycle protein 16 homolog (Gene Name=CDC16)

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