Structure of PDB 6rwl Chain J Binding Site BS01

Receptor Information
>6rwl Chain J (length=252) Species: 11723 (Simian immunodeficiency virus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
FLDGIEKAQEEHEKYHNNWRAMAEDFQIPQVVAKEIVAQCPKCQSPKTWQ
MDCTHLEGKVIIVAVHVASGYIEAEVLPAETGKETAHFLLKLAARWPVKH
LHTDNGDNFTSSAVQAVCWWAQIEHTFGVVESMNHQLKTIITQIRDQAEK
IETAVQMAVLIHNFKRKGGIGGYSAGERIIDIIASDLQTTKLQNQISKIQ
NFRVYFREGRDQQWKGPATLIWKGEGAVVIQDGQDLKVVPRRKCKIIKDY
GR
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain6rwl Chain J Residue 500 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6rwl Structural basis of second-generation HIV integrase inhibitor action and viral resistance.
Resolution3.36 Å
Binding residue
(original residue number in PDB)		H12 H16 C40 C43
Binding residue
(residue number reindexed from 1)		H12 H16 C40 C43
Annotation score4
Enzymatic activity
Enzyme Commision number 3.1.13.2: exoribonuclease H.
3.1.26.13: retroviral ribonuclease H.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0008270 zinc ion binding
Biological Process
GO:0015074 DNA integration

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6rwl, PDBe:6rwl, PDBj:6rwl
PDBsum6rwl
PubMed32001525
UniProtE1ANT8

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