Structure of PDB 6nud Chain J Binding Site BS01

Receptor Information
>6nud Chain J (length=741) Species: 1308 (Streptococcus thermophilus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KEKIDLFYGALLHDIGKVIQRATGERKKHALVGADWFDEIADNQVISDQI
RYHMANYQSDKLGNDHLAYITYIADNIASGSAKIWDTYTNQADIFNVFGA
QTDKRYFKPTVLNLKSKPNFASATYEPFSKGDYAAIATRIKNELAEFEFN
QAQIDSLLNLFEAILSFVPSSTNSKEIADISLAEHSRLTAAFALAIYDYL
EDKGRHNYKEDLFTKASAFYEEEAFLLASFDLSGIQDFIYNIATSGAAKQ
LKARSLYLDFMSEYIADSLLDKLGLNRANLLYVGGGHAYFVLANTEKTVE
TLVQFEKDFNQFLLANFQTRLYVAFGWGSFAAKDIMSELNSPESYRQIYQ
KASRMISEKKISRYDYRTLMLLNRGGKSSERECEICHSVENLVSYHDQKV
CDICRGLYQFSKEIAHDHFIITENEGLPIGPNACLKGVAFEKLSQESFSR
VYVKNDYKAGTIKATHVFVGDYQCDEIHKYAALSKNEDGLGIKRLAVVRL
DVDDLGAAFMAGFSRQGNGQYSTLSRSATFSRSMSLFFKVYINQFASDKK
LSIIYAGGDDVFAIGSWQDIIAFTVELRQNFIKWTNGKLTLSAGIGLFAD
KTPISLMAHQTGELEEAAKGNEKDSISLFSSDYTFKFDRFITNVYDDKLE
QIRYFFNHQDERGKNFIYKLIELLRNYESEEKMNVARLAYYLTRLEELTD
KDERDKFKQFKKLFFKWYTNNESDRKEAELALLLYVYEIRK
Ligand information
>6nud Chain U (length=28) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
aagugaacagaauuaaacaguuacgaaa
............................
Receptor-Ligand Complex Structure
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PDB6nud Coupling of ssRNA cleavage with DNase activity in type III-A CRISPR-Csm revealed by cryo-EM and biochemistry.
Resolution3.5 Å
Binding residue
(original residue number in PDB)		K617 E677 R678 K680 N681 L714 R756 K757
Binding residue
(residue number reindexed from 1)		K601 E661 R662 K664 N665 L698 R740 K741
Enzymatic activity
Enzyme Commision number 2.7.7.-
3.1.-.-
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0004519 endonuclease activity
GO:0004527 exonuclease activity
GO:0005524 ATP binding
GO:0016740 transferase activity
Biological Process
GO:0051607 defense response to virus

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Molecular Function
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Biological Process
External links
PDB RCSB:6nud, PDBe:6nud, PDBj:6nud
PDBsum6nud
PubMed30814678
UniProtA0A0A7HFE1|CAS10_STRTR CRISPR system single-strand-specific deoxyribonuclease Cas10/Csm1 (subtype III-A) (Gene Name=cas10)

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