Structure of PDB 6lc1 Chain J Binding Site BS01

Receptor Information
>6lc1 Chain J (length=86) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GRCAVCGDNASCQHYGVRTCEGCKGFFKRTVQKNAKYICLANKDCPVDKR
RRNRCQFCRFQKCLAVGMVKEVVRTDSLKGRRGRLP
Ligand information
Receptor-Ligand Complex Structure
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PDB6lc1 Structural basis of NR4A1 bound to the human pituitary proopiomelanocortin gene promoter.
Resolution3.12 Å
Binding residue
(original residue number in PDB)		Q277 H278 Y279 Q296 V336 V337 R338 R346
Binding residue
(residue number reindexed from 1)		Q13 H14 Y15 Q32 V72 V73 R74 R82
Binding affinityPDBbind-CN: Kd=135.33nM
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003700 DNA-binding transcription factor activity
GO:0008270 zinc ion binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:6lc1, PDBe:6lc1, PDBj:6lc1
PDBsum6lc1
PubMed31822342
UniProtP22736|NR4A1_HUMAN Nuclear receptor subfamily 4immunitygroup A member 1 (Gene Name=NR4A1)

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