Structure of PDB 6fec Chain J Binding Site BS01

Receptor Information
>6fec Chain J (length=53) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QQLYWSHPRKFGQGSRSCRVCSNRHGLIRKYGLNMCRQCFRQYAKDIGFI
KLD
Ligand information
>6fec Chain A (length=1776) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uaccugguugauccugccaguagcauaugcuugucucaaagauuaagcca
ugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucau
uaaaucaguuaugguuccuuuggucgcucgcuccucuccuacuuggauaa
cugugguaauucuagagcuaauacaugccgacggcgcugacucccuuugu
gugggaugcgugcauuuaucagaucaaaaccaacccggucagcggcggcg
gcuuuggugacucuagauaaccucgggccgaucgcagcccuccguggcgg
cgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccg
ugccuaccauggugaccacgggugacggggaaucaggguucgauuccgga
gagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgc
aaauuacccacucccgacccggggagguagugacgaaaaauaacaauaca
ggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuuua
acgaggauccauuggagggcaagucuggucgcagcagccgcgguaauucc
agcuccaauagcguauauuaaaguugcugcaguuaaaaagcucguaguug
gaucuugagggcccgccccucggcgcccccucgaugugucccgcggggcc
cgaagcguuuacuuugaaaaaauuagaguguucaaagcaggcccgagccg
ccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuug
uugguuuucggaacugaggccaugauuaagagggacggccgggggcauuc
guauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccag
agcgaaagcauuugccaagaauguuuucauuaaucaagaacgaaagucgg
agguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugcc
gacuggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgg
gaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaac
uuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaa
uuugacucaacacgggaaaccucacccggcccggacacggacaggauuga
cagauugauagcucuuucucgauucugugggugguggugcauggccguuc
uuaguugguggagcgauuugucugguuaauuccgauaacgaacgagacuc
uggcaugcuaacuaguuacgcgacccccgagcggucggcgucccccaacu
ucuuagagggacaaguggcguucagccacccgagauugagcaauaacagg
ucugugaugcccuuagaugucggggcugcacgcgcgcuacacugacuggc
ucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccc
cauucgugauggggaucggggauugcaauuauuccccaugaacgaggaau
ucccaguaagugcgggucauaagcuugcguugauuaagucccugcccuuu
guacacaccgcccgucgcuacuaccgauuggaugguuuagugaggcccuc
ggaucggcccgccggggucggcccacggcccuggcggagcgcugagaaga
cggucgaacuugacuaucuagaggaaguaaaagucguaacaagguuuccg
uaggugaaccugcggaaggaucauua
...<<<<<...[[[[>>>>>[[[.((((((................[[[.
[[[...<....<.....<<..........>>....>.>.......{{...
.....[[[.{..........[[[[[..................<<.....
<<..<.......>..>>......>>..........<<...<<........
..>>...>>..[[..(((((.......<<<<<<<<<<.<........>>>
>..............)))))......]]...<<<...<<......>>...
>>>.]].]]].......}.]]].<<<....<<<.....<<<<<<......
...>>>>>>.>>>......>>>...<<<.<<<<....>>>>....>>>.}
}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]]....
.....<<<....<<<.....>>>..>>>...............<<<.<<<
<<.<<<....>>>.>.>>>>..>>>......<..................
.>.........<<<<<((......<<<<.........)).........>>
>>.>>>>>..)))))).]]]............<<.......{{...[[[.
[[....<.<..>.>..........<<<<<...............>>>>>.
........<<<<<..........<<..............<<<.......>
>>....>>.........>>..>>>.......[[....[.(((((.....>
>>>>>>...))))).]...]]....]]....<<<<<<..<...<<<<..<
<<.<<<<<<<<...<<<......>>>......>>>>>>>>.>>>......
.<<....>>...>>>>..>..>>>.>>>...]]]...}}......<<<<<
.....<...<<.............>>...>..>>>>>..........<<<
.<<.<<<..<.<<<<<<.<<<<......>>>>>>>>>>.>..>>>...<<
..>>>>...>>.....>>>......<<......<<<......>>>....>
>...]]]]..<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<<<....
..<<........>>..........<<<<<.......<<<<<.......<<
.<<<........>>>.>>.....>>>>>....<..<<<....<<<<<<..
...<<<.<<<<......>>...<<<......>>>...>>.>>>....<<<
.......<<<<..<<<<.......<..<<<....>>>>........>>>>
..>>>>........<<<<<.....>>>>>........>>>.....>>.>>
>...>...>>>.>......>>>>>...>>.>>>>.>>>.....<<.<<<.
.......<.......<<<.<<<<....>>>>.>>>....>.........>
>>.>>..........<.<<<<<..........>>>>>>..........>>
>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>
>>.>>.......<<.....<<<.<<....<<<<<<<<.<<...<<<<..<
...<<<<<<<<<<<<<<...........>>>>>>>>>...>>>>>...>.
.>>>>...>>.>>>>>>>>...>>.>>>......>>.........<<<<<
<<<<....>>>>>>>>>.........
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6fec Structure of a human cap-dependent 48S translation pre-initiation complex.
Resolution6.3 Å
Binding residue
(original residue number in PDB)		Q4 Q5 L6 Y7 W8 S9 H10 P11 R12 K13 F14 G15 Q16 G17 S18 R19 C24 R27 H28 L30 I31 R32 K33 Y34 R40 Q41 C42 Q45 L55 D56
Binding residue
(residue number reindexed from 1)		Q1 Q2 L3 Y4 W5 S6 H7 P8 R9 K10 F11 G12 Q13 G14 S15 R16 C21 R24 H25 L27 I28 R29 K30 Y31 R37 Q38 C39 Q42 L52 D53
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
Biological Process
GO:0002181 cytoplasmic translation
GO:0006412 translation
Cellular Component
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005791 rough endoplasmic reticulum
GO:0005829 cytosol
GO:0005840 ribosome
GO:0005925 focal adhesion
GO:0015935 small ribosomal subunit
GO:0022626 cytosolic ribosome
GO:0022627 cytosolic small ribosomal subunit
GO:0070062 extracellular exosome
GO:0098556 cytoplasmic side of rough endoplasmic reticulum membrane
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6fec, PDBe:6fec, PDBj:6fec
PDBsum6fec
PubMed29401259
UniProtP62273|RS29_HUMAN Small ribosomal subunit protein uS14 (Gene Name=RPS29)

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