Structure of PDB 6f38 Chain J Binding Site BS01

Receptor Information
>6f38 Chain J (length=369) Species: 9823 (Sus scrofa) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EKTAVVIDLGEAFTKCGFAGETGPRCIIPSVIKKAGMPKPIKVVQYNINT
EELYSYLKEFIHILYFRHLLVNPRDRRVVVIESVLCPSHFRETLTRVLFK
YFEVPSVLLAPSHLMALLTLGINSAMVLDCGYRESLVLPIYEGIPVLNCW
GALPLGGKALHKELETQLLEQCTVDTGQSLPSVMGSIPEGVLEDIKVRTC
FVSDLTRGLKIQAAKFNRPSPPPNVDYPLDGEKILHVLGSIRDSVVEILF
EQDNEEKSVATLILDSLMQCPIDTRKQLAENLVIIGGTSMLPGFLHRLLA
EIRYLVEKPKYKKTLGTKTFRIHTPPAKANCVAWLGGAIFGALQDILGSR
SVSKEYYNQTGRIPDWCSL
Ligand information
Ligand IDADP
InChIInChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1
InChIKeyXTWYTFMLZFPYCI-KQYNXXCUSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0c1nc(c2c(n1)n(cn2)[C@H]3[C@@H]([C@@H]([C@H](O3)CO[P@](=O)(O)OP(=O)(O)O)O)O)N
CACTVS 3.341Nc1ncnc2n(cnc12)[CH]3O[CH](CO[P](O)(=O)O[P](O)(O)=O)[CH](O)[CH]3O
ACDLabs 10.04O=P(O)(O)OP(=O)(O)OCC3OC(n2cnc1c(ncnc12)N)C(O)C3O
CACTVS 3.341Nc1ncnc2n(cnc12)[C@@H]3O[C@H](CO[P@@](O)(=O)O[P](O)(O)=O)[C@@H](O)[C@H]3O
OpenEye OEToolkits 1.5.0c1nc(c2c(n1)n(cn2)C3C(C(C(O3)COP(=O)(O)OP(=O)(O)O)O)O)N
FormulaC10 H15 N5 O10 P2
NameADENOSINE-5'-DIPHOSPHATE
ChEMBLCHEMBL14830
DrugBankDB16833
ZINCZINC000012360703
PDB chain6f38 Chain J Residue 800 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6f38 Cryo-EM shows how dynactin recruits two dyneins for faster movement.
Resolution6.7 Å
Binding residue
(original residue number in PDB)		G21 E22 A23 F24 Y143 C215 T309 M311 L312
Binding residue
(residue number reindexed from 1)		G10 E11 A12 F13 Y132 C200 T288 M290 L291
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Biological Process
GO:0098958 retrograde axonal transport of mitochondrion
Cellular Component
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005869 dynactin complex
GO:1904115 axon cytoplasm

View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6f38, PDBe:6f38, PDBj:6f38
PDBsum6f38
PubMed29420470
UniProtI3LHK5|ARP10_PIG Actin-related protein 10 (Gene Name=ACTR10)

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