Structure of PDB 6f1t Chain J Binding Site BS01

Receptor Information
>6f1t Chain J (length=369) Species: 9823 (Sus scrofa) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EKTAVVIDLGEAFTKCGFAGETGPRCIIPSVIKKAGMPKPIKVVQYNINT
EELYSYLKEFIHILYFRHLLVNPRDRRVVVIESVLCPSHFRETLTRVLFK
YFEVPSVLLAPSHLMALLTLGINSAMVLDCGYRESLVLPIYEGIPVLNCW
GALPLGGKALHKELETQLLEQCTVDTGQSLPSVMGSIPEGVLEDIKVRTC
FVSDLTRGLKIQAAKFNRPSPPPNVDYPLDGEKILHVLGSIRDSVVEILF
EQDNEEKSVATLILDSLMQCPIDTRKQLAENLVIIGGTSMLPGFLHRLLA
EIRYLVEKPKYKKTLGTKTFRIHTPPAKANCVAWLGGAIFGALQDILGSR
SVSKEYYNQTGRIPDWCSL
Ligand information
Ligand IDADP
InChIInChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1
InChIKeyXTWYTFMLZFPYCI-KQYNXXCUSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0c1nc(c2c(n1)n(cn2)[C@H]3[C@@H]([C@@H]([C@H](O3)CO[P@](=O)(O)OP(=O)(O)O)O)O)N
CACTVS 3.341Nc1ncnc2n(cnc12)[CH]3O[CH](CO[P](O)(=O)O[P](O)(O)=O)[CH](O)[CH]3O
ACDLabs 10.04O=P(O)(O)OP(=O)(O)OCC3OC(n2cnc1c(ncnc12)N)C(O)C3O
CACTVS 3.341Nc1ncnc2n(cnc12)[C@@H]3O[C@H](CO[P@@](O)(=O)O[P](O)(O)=O)[C@@H](O)[C@H]3O
OpenEye OEToolkits 1.5.0c1nc(c2c(n1)n(cn2)C3C(C(C(O3)COP(=O)(O)OP(=O)(O)O)O)O)N
FormulaC10 H15 N5 O10 P2
NameADENOSINE-5'-DIPHOSPHATE
ChEMBLCHEMBL14830
DrugBankDB16833
ZINCZINC000012360703
PDB chain6f1t Chain J Residue 800 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6f1t Cryo-EM shows how dynactin recruits two dyneins for faster movement.
Resolution3.5 Å
Binding residue
(original residue number in PDB)		A23 G142 Y143 K211 G308 M311 N351
Binding residue
(residue number reindexed from 1)		A12 G131 Y132 K196 G287 M290 N330
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Biological Process
GO:0098958 retrograde axonal transport of mitochondrion
Cellular Component
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005869 dynactin complex
GO:1904115 axon cytoplasm

View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6f1t, PDBe:6f1t, PDBj:6f1t
PDBsum6f1t
PubMed29420470
UniProtI3LHK5|ARP10_PIG Actin-related protein 10 (Gene Name=ACTR10)

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