Structure of PDB 6ahr Chain J Binding Site BS01

Receptor Information
>6ahr Chain J (length=247) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AVFADLDLRAGSDLKALRGLVETAAHLGYSVVAINHIVDFKEKKQEIEKP
VAVSELFTTLPIVQGKSRPIKILTRLTIIVSDPSHCNVLRATSSRARLYD
VVAVFPKTEKLFHIACTHLDVDLVCITVTEKLPFYFKRPPINVAIDRGLA
FELVYSPAIKDSTMRRYTISSALNLMQICKGKNVIISSAAERPLEIRGPY
DVANLGLLFGLSESDAKAAVSTNCRAALLHGETRKTAFGIISTVKKP
Ligand information
>6ahr Chain A (length=341) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
auagggcggagggaagcucaucaguggggccacgagcugagugcguccug
ucacuccacucccaugucccuugggaaggucugagacuagggccagaggc
ggcccuaacagggcucucccugagcuucggggaggugaguucccagagaa
cggggcuccgcgcgaggucagacugggcaggagaugccguggaccccgcc
cuucggggaggggcccggcggaugccuccuuugccggagcuuggaacaga
cucacggccagcgaagugaguucaauggcugaggugagguaccccgcagg
ggaccucauaacccaauucagacuacucuccuccgcccauu
<<.<<<<<<<<<.<..((((.....<<<<..........<<<<.......
.>>>>............>>>>..[...<..<<<<<.....<<<.......
<<<<<.....>>>>><<<<<<<.....>>>>>>><<<<<<<.........
....<<<<<<.<<<<<<.......<<<<<.....<<<<<.<<.<<<<.<<
<....>>>.>>>>>>>>>>>..>>>>>>>>>.>>>>>>>>........>>
>>>>>.>>>....................))))<<<<<<<.<<<<...>>
>>>>>>>>>..]....>>>>>.>.....>>>>>>>>>>>>.
Receptor-Ligand Complex Structure
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PDB6ahr Cryo-EM Structure of the Human Ribonuclease P Holoenzyme.
Resolution3.92 Å
Binding residue
(original residue number in PDB)		R139 K181
Binding residue
(residue number reindexed from 1)		R138 K180
Enzymatic activity
Enzyme Commision number 3.1.26.5: ribonuclease P.
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0004526 ribonuclease P activity
GO:0005515 protein binding
GO:0033204 ribonuclease P RNA binding
Biological Process
GO:0001682 tRNA 5'-leader removal
GO:0006364 rRNA processing
GO:0008033 tRNA processing
Cellular Component
GO:0000172 ribonuclease MRP complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005655 nucleolar ribonuclease P complex
GO:0005730 nucleolus
GO:0030681 multimeric ribonuclease P complex

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Biological Process
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Cellular Component
External links
PDB RCSB:6ahr, PDBe:6ahr, PDBj:6ahr
PDBsum6ahr
PubMed30454648
UniProtP78346|RPP30_HUMAN Ribonuclease P protein subunit p30 (Gene Name=RPP30)

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