Structure of PDB 6ahd Chain J Binding Site BS01

Receptor Information
>6ahd Chain J (length=227) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LGVYLTKKEQKKLRRQTRREAQKELQEKVRLGLMPPPEPKVRISNLMRVL
GTEAVQDPTKVEAHVRAQMAKRQKAHEEANAARKLTAEQRKVKKIKKLKE
DISQGVHISVYRVRNLSNPAKKFKIEANAGQLYLTGVVVLHKVVVVEGGP
KAQKKFKRLMLHRIKWDEQTSNTKGDDDEKKTNKCVLVWEGTAKDRSFGE
MKFKQCPTENMAREHFKKHGAEHYWDL
Ligand information
>6ahd Chain I (length=136) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
agcuuugcgcaguggcaguaucguagccaaugaggucuauccgaggcgcg
auuauugcuaauuacuuuucccaauaccccgccgugacgacuugcaauau
agucggcacuggcaauuuuugacagucucgagacug
...................<<<<<.<<<.....<<.....>>..>>>>>>
>>............................<<<<<<.<<<<<........
>>>>>.>>>.>>>.........<<<<<<<>>>>>>>
Receptor-Ligand Complex Structure
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PDB6ahd Structures of the human pre-catalytic spliceosome and its precursor spliceosome.
Resolution3.8 Å
Binding residue
(original residue number in PDB)		K447 R449 R450 R453 Q461 M504 H511 R518
Binding residue
(residue number reindexed from 1)		K12 R14 R15 R18 Q26 M69 H76 R83
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0042802 identical protein binding
Biological Process
GO:0000244 spliceosomal tri-snRNP complex assembly
GO:0000375 RNA splicing, via transesterification reactions
GO:0000398 mRNA splicing, via spliceosome
GO:0006397 mRNA processing
GO:0008380 RNA splicing
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005681 spliceosomal complex
GO:0005829 cytosol
GO:0015030 Cajal body
GO:0016607 nuclear speck
GO:0032991 protein-containing complex
GO:0046540 U4/U6 x U5 tri-snRNP complex
GO:0071005 U2-type precatalytic spliceosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6ahd, PDBe:6ahd, PDBj:6ahd
PDBsum6ahd
PubMed30315277
UniProtO43395|PRPF3_HUMAN U4/U6 small nuclear ribonucleoprotein Prp3 (Gene Name=PRPF3)

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