Structure of PDB 5y88 Chain J Binding Site BS01

Receptor Information
>5y88 Chain J (length=431) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KGGVWTNVEDQILKAAVQKYGTHQWSKVASLLQKKTARQSELRWNEYLNP
KLNFTEFSKEEDAQLLDLARELPNQWRTIADMMARPAQVCVERYNRLLES
EDSEDEEKEMLAEARARLLNTQGKKATRKIRERMLEESKRIAELQKRREL
KQAGINVAIKKPKKKYGTDIDYNEDIVYEQAPMPGIYDTSTEDRQIKKKF
EQFERKVNRKGLLTPKELLPHDSGQEDNERSNIKSGKQLKSRIRKFFASL
PSPKNDFEIDEKEEDAEIAEYEKEEDNFIEPPSQPRVSLVAVPLAYSTLK
NNPQSAIDNKYNLLVANAINKEPHMESRMQHITQGRTSMKIQFKTAMPPT
EVLLESIQSKVESIEQLQRKLQHVQPLEQQNNEMCSTLCHHSLPALIEGQ
RKYYADYYAYRQEIRSLEGRRKRLQAMLNSS
Ligand information
>5y88 Chain D (length=101) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
guucgcgaaguaacccuucguggacauuuggucaauuugaaacaauacag
agaugaucagcaguuccccugcauaaggaugaaccguuuuacaaagagau
u
<<<<<<<<<<.....>>>>>>>>>>.........................
............<<<..<<<.....>>>...>>>................
.
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB5y88 Structure of an Intron Lariat Spliceosome from Saccharomyces cerevisiae
Resolution3.46 Å
Binding residue
(original residue number in PDB)		K35 S38 R158 K165 K166 A167 R169 R174 Y207 Y219
Binding residue
(residue number reindexed from 1)		K27 S30 R117 K124 K125 A126 R128 R133 Y166 Y178
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0000386 second spliceosomal transesterification activity
GO:0003677 DNA binding
GO:0005515 protein binding
Biological Process
GO:0000350 generation of catalytic spliceosome for second transesterification step
GO:0000398 mRNA splicing, via spliceosome
GO:0006397 mRNA processing
GO:0008380 RNA splicing
Cellular Component
GO:0000974 Prp19 complex
GO:0005634 nucleus
GO:0005681 spliceosomal complex
GO:0005737 cytoplasm
GO:0071006 U2-type catalytic step 1 spliceosome

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:5y88, PDBe:5y88, PDBj:5y88
PDBsum5y88
PubMed28919079
UniProtQ03654|CEF1_YEAST Pre-mRNA-splicing factor CEF1 (Gene Name=CEF1)

[Back to BioLiP]