Structure of PDB 5whb Chain J Binding Site BS01

Receptor Information
>5whb Chain J (length=157) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MTEYKLVVVGAVGVGKSALTIQLIQNHFDSYRKQVVIDGETCLLDILDTA
GQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDV
PMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQGVDDAFYTL
VREIRKH
Ligand information
>5whb Chain K (length=29) Species: 32630 (synthetic construct) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
RPRCPGDDASIEDLHEYWARLWNYLYRVA
Receptor-Ligand Complex Structure
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PDB5whb Exceptionally high-affinity Ras binders that remodel its effector domain.
Resolution2.18 Å
Binding residue
(original residue number in PDB)		E3 K5 Y40 R41 I55 L56 D57 T58 E63 R68 Y71 M72
Binding residue
(residue number reindexed from 1)		E3 K5 Y31 R32 I46 L47 D48 T49 E54 R59 Y62 M63
Enzymatic activity
Enzyme Commision number 3.6.5.2: small monomeric GTPase.
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding
Biological Process
GO:0007165 signal transduction
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5whb, PDBe:5whb, PDBj:5whb
PDBsum5whb
PubMed29282294
UniProtP01116|RASK_HUMAN GTPase KRas (Gene Name=KRAS)

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