Structure of PDB 5nrl Chain J Binding Site BS01

Receptor Information
>5nrl Chain J (length=800) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PSFLDQEPPAGYVPGIGRGATGFDDEAANVFKTLELKLAQSNVKRQFADL
KESLAAVTESEWMDIPDATDFTRRNKRNRIQEQLNRKTYAAPDSLIPGNV
DLNKLTEEREKLLQSQIDENLVNSLSDATLEDLQKMRTILKSYRKADPTN
PQGWIASARLEEKARKFSVAKKIIENGCQECPRSSDIWLENIRLHESDVH
YCKTLVATAINFNPTSPLLWFKAIDLESTTVNKYRVVRKALQEIPRDEGL
WKLAVSFEADKAQVIKMLEKATQFIPQSMDLLTAYTNLQSYHNAKMTLNS
FRKILPQEPEIWIISTLLEERNNPDIPVDKLVSLLKEGLLELSKNGYKAT
LSAWLKRAEALNDAPNSNLTCQAIVYAILEWLRESGEYESELNNVDQILE
KMPHSKVQIAVLKKLIQWDPCDTVLWSRLKMATESYEELLAFFQELLFQT
DDIRANMREKSPGLLMMYVSEYWKAQKGDTRQTLVLIDQIIDFAPHNLDL
RFFKIKLLGRSLQLDELRDFFQQTFSSLEDFKISGTERLYYKYVNFLRYQ
DLNEEAIKFLNERCLKSFPICHKFFLQLGQIYHSMGNIEMSRETYLSGTR
LVPNCPLLWVSLSKIDEIDLKNPVRARSILDRGLLKNPDDVLFYIAKIQM
EIRLGNLDQAELLVTQALQKFPSNALLWVEQIKLFKHGNKSSLKKTIFQD
ALRRTQNDHRVLLEIGVSFYAEAQYETSLKWLERALKKCSRYGDTWVWLF
RTYARLGKDTVDLYNMFDQCEPTYGPEWIAASKNVKMQYCTPREILLRLM
Ligand information
>5nrl Chain 4 (length=114) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
auccuuaugcacgggaaauacgcauaucagugaggauucguccgagauug
uguuuuugcugguugaaauaauuauaacuccucauggucagacuauguag
ggaauuuuuggaau
Receptor-Ligand Complex Structure
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PDB5nrl Structure of a pre-catalytic spliceosome.
Resolution7.2 Å
Binding residue
(original residue number in PDB)		N132 K133 R136 Q140 L141 R143 K144 Y146 S788 L789 K791
Binding residue
(residue number reindexed from 1)		N75 K76 R79 Q83 L84 R86 K87 Y89 S692 L693 K695
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003674 molecular_function
GO:0005515 protein binding
Biological Process
GO:0000244 spliceosomal tri-snRNP complex assembly
GO:0000398 mRNA splicing, via spliceosome
GO:0006396 RNA processing
GO:0006397 mRNA processing
GO:0008150 biological_process
GO:0008380 RNA splicing
Cellular Component
GO:0005634 nucleus
GO:0005681 spliceosomal complex
GO:0005682 U5 snRNP
GO:0046540 U4/U6 x U5 tri-snRNP complex
GO:0071001 U4/U6 snRNP
GO:0071013 catalytic step 2 spliceosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5nrl, PDBe:5nrl, PDBj:5nrl
PDBsum5nrl
PubMed28530653
UniProtP19735|PRP6_YEAST Pre-mRNA-splicing factor 6 (Gene Name=PRP6)

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