Structure of PDB 5iud Chain J Binding Site BS01

Receptor Information
>5iud Chain J (length=861) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EQVFHFYWLDAYEDQYNQPGVVFLFGKVWIESAETHVSCCVMVKNIERTL
YFLPREMKIDLNTGKETGTPISMKDVYEEFDEKIATKYKIMKFKSKPVEK
NYAFEIPDVPEKSEYLEVKYSAEMPQLPQDLKGETFSHVFGTNTSSLELF
LMNRKIKGPCWLEVKSPQLLNQPVSWCKVEAMALKPDLVNVIKDVSPPPL
VVMAFSMKTMQNAKNHQNEIIAMAALVHHSFALDKAAPKPPFQSHFCVVS
KPKDCIFPYAFKEVIEKKNVKVEVAATERTLLGFFLAKVHKIDPDIIVGH
NIYGFELEVLLQRINVCKAPHWSKIGRLKRSNMPKLFGERNATCGRMICD
VEISAKELIRCKSYHLSELVQQILKTERVVIPMENIQNMYSESSQLLYLL
EHTWKDAKFILQIMCELNVLPLALQITNIAGNIMSRTLMGGRSERNEFLL
LHAFYENNYIVPDKQIKAAYAGGLVLDPKVGFYDKFILLLDFNSLYPSII
QEFNICFTTVQRQIPELPDPSLEMGILPREIRKLVERRKQVKQLMKQQDL
NPDLILQYDIRQKALKLTANSMYGCLGFSYSRFYAKPLAALVTYKGREIL
MHTKEMVQKMNLEVIYGDTDSIMINTNSTNLEEVFKLGNKVKSEVNKLYK
LLEIDIDGVFKSLLLLKKKKYAALVVEPTSDGNYVTKQELKGLDIVRRDW
CDLAKDTGNFVIGQILSDQSRDTIVENIQKRLIEIGENVLNGSVPVSQFE
INKALTKDPQDYPDKKSLPHVHVALWINSQGGRKVKAGDTVSYVICQDGS
NLTASQRAYAPEQLQKQDNLTIDTQYYLAQQIHPVVARICEPIDGIDAVL
IATWLGLDPTQ
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB5iud Human DNA polymerase alpha in binary complex with a DNA:DNA template-primer.
Resolution3.3 Å
Binding residue
(original residue number in PDB)		G783 R784 S785 Y839 A840 G841 G958 G961 F962 K1052 K1054 T1187 S1189 R1222
Binding residue
(residue number reindexed from 1)		G441 R442 S443 Y470 A471 G472 G574 G577 F578 K668 K670 T803 S805 R838
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
Biological Process
GO:1902975 mitotic DNA replication initiation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:5iud, PDBe:5iud, PDBj:5iud
PDBsum5iud
PubMed27032819
UniProtP09884|DPOLA_HUMAN DNA polymerase alpha catalytic subunit (Gene Name=POLA1)

[Back to BioLiP]