Structure of PDB 5gap Chain J Binding Site BS01

Receptor Information
>5gap Chain J (length=729) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GNVDLNKLTEEREKLLQSQIDENLAQLTKNASNPIQVNKPNAATDALSYL
KDLENDRVNSLSDATLEDLQKMRTILKSYRKADPTNPQGWIASARLEEKA
RKFSVAKKIIENGCQECPRSSDIWLENIRLHESDVHYCKTLVATAINFNP
TSPLLWFKAIDLESTTVNKYRVVRKALQEIPRDEGLWKLAVSFEADKAQV
IKMLEKATQFIPQSMDLLTAYTNLQSYHNAKMTLNSFRKILPQEPEIWII
STLLEERNNPKLVSLLKEGLLELSKNGYKATLSAWLKRAEALNDAPNSNL
TCQAIVYAILEWLRESGEYESELNNVDQILEKMPHSKVQIAVLKKLIQWD
PCDTVLWSRLKMATESYEELLAFFQELLFQTSDDIRANMREKSPGLLMMY
VSEYWKAQKGDTRQTLVLIDQIIDFAPHNLDLRFFKIKLLGRSLQLDELR
DFFQQTFSSLEDFKISGTERLYYKYVNFLRYQDLNEEAIKFLNERCLKSF
PICHKFFLQLGQIYHSMGNIEMSRETYLSGTRLVPNCPLLWVSLSKIDEI
DLKNPVRARSILDRGLLKNPDDVLFYIAKIQMEIRLGNLDQAELLVTQAL
QKFPSNALLWVEQIKLFKHGNKSSLKKTIFQDALRRTQNDHRVLLEIGVS
FYAEAQYETSLKWLERALKKCSRYGDTWVWLFRTYARLGKDTVDLYNMFD
QCEPTYGPEWIAASKNCTPREILLRLMND
Ligand information
>5gap Chain V (length=67) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
auccuuaugcacgggaaauacgcauaucagugaggauucguccgagauug
uguuuuugcugguugaa
...................<<<<<.<<<.....<<<....>>>..>>>>>
>>>..............
Receptor-Ligand Complex Structure
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PDB5gap Cryo-EM structure of the yeast U4/U6.U5 tri-snRNP at 3.7 angstrom resolution.
Resolution3.6 Å
Binding residue
(original residue number in PDB)		P188 I189 A196 A197 D199 A200 L201 Y203 S788 K791
Binding residue
(residue number reindexed from 1)		P34 I35 A42 A43 D45 A46 L47 Y49 S624 K627
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003674 molecular_function
GO:0005515 protein binding
Biological Process
GO:0000244 spliceosomal tri-snRNP complex assembly
GO:0000398 mRNA splicing, via spliceosome
GO:0006396 RNA processing
GO:0006397 mRNA processing
GO:0008150 biological_process
GO:0008380 RNA splicing
Cellular Component
GO:0005634 nucleus
GO:0005681 spliceosomal complex
GO:0005682 U5 snRNP
GO:0046540 U4/U6 x U5 tri-snRNP complex
GO:0071001 U4/U6 snRNP
GO:0071013 catalytic step 2 spliceosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5gap, PDBe:5gap, PDBj:5gap
PDBsum5gap
PubMed26829225
UniProtP19735|PRP6_YEAST Pre-mRNA-splicing factor 6 (Gene Name=PRP6)

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