Structure of PDB 5anc Chain J Binding Site BS01

Receptor Information
>5anc Chain J (length=250) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MSIFTPTNQIRLTNVAVVRMKRAGKRFEIACYKNKVVGWRSGVEKDLDEV
LQTHSVFVNVSKGQVAKKEDLISAFGTDDQTEICKQILTKGEVQVSDKER
HTQLEQMFRDIATIVADKCVNPETKRPYTVILIERAMKDIHYSVKTNKST
KQQALEVIKQLKEKMKIERAHMRLRFILPVNEGKKLKEKLKPLIKVIESE
DYGQQLEIVCLIDPGCFREIDELIKKETKGKGSLEVLNLKDVEEGDEKFE
Ligand information
>5anc Chain N (length=1162) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
auuagcaguuucgggggcguaaugcucucagcugauucucaaacucugaa
cauuuuugguaagcagaacuggcgauguggguugaaccaaauauugggau
aagacgucuaacauucacuaauagauaccacaaaagguguuaguucauua
agacagcaggacgguggccauggaagucgguauccgcuaaggagugugua
acaacucaccugccaaauggacuagcccugaaaauggaugacgcuagcag
uggauggucgaugcccaaucguuaaaagaagugauaauacuuuuaacaau
ccaacuguuuaauuaaaacaaagcauugcgauaagcuuaaaagcuuuuga
cgcaaugugauuucugcccagugcucugaaugucaaagugaagagauuca
accuagcacggguaaacggcgggaguaacuaugacucucuuaagguagcc
aaaugccucgucaucuaauuagugacgcgcaugaauggaucaaugagauu
cccacugucccuaacuacuauacagcgaaaccacugcaaggggaacgggc
cuugcaaaaacagcggggaaagaagacccuguugagcuugacucuagucu
gauauuaacaguuucagguggggaguuuggcuggggcggcacauuuguua
aaagauaacgcaaguguccaaaggcaggcucagugagaacagaaaucuca
cguagaguaaaagggcaaaagccugcuugauucugauuuucaguacuaau
cggaacugggaaaccagggccuaucgauccuuuaugugcuuaaaucuuaa
cccuagaggugucagaaaaguuaccacagggauaacuggcuuguggcagc
caagcgcucauagcgacgcugcuuuuugauccuucgaugucggcucuucu
uaucauugugaagcagaauucacaaaguguuggauuguucacccacuaac
aaggaacgugagcuggguuuagaccgucgugagacagguuaguuuuaccc
uacuguugucaauuguuugcguaauaguagcaugauuuaguacgagagga
acugucaugccggaucacuggucuguagguuuauuugacaaaauagugac
cugccgcuaccauccguuggauaauggcugaacgccucuaagucagaauc
cauucuagaaac
...<.<<<<<..<<<<<<.....>>>>>>>>>>>.>..............
<<.<<<<<.....>>>>>.>>......<<<......>>>...<<<<<<..
..<<<(((...<<<<<<<....<<..........<<<.<<<<<<<<<<..
.....<<<<<.<<<..<<<.........>>>..>>>.........<<...
...>>...>>>>>...>>>>>>>>>>>>>..........))).>>....>
>>>>>>>>>....>>>>>>.<<<<<<<<...........>>>>>>>><<<
<<<..<<<.........>>>..<<<<<<<....<<<<....>>>>.....
.>>>>>>>...<<..<<<..<<<<<<.....<<....<<<<<....>>>>
.>...>>..>>>>..>>>>><<<<<<.......>>>>>>........<..
.........<<<<<.......>>>>>.....>.....>>....>>.>>>>
....................................<<<<<........>
>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<
<<.<<.....>>.>>>>>>..>>>>>...<<<.....>>>..<<<<<<..
.........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>
>.....<<[..(((>>....>>>>>>>...<<<<<<<<.........>>>
>>>>>.<<<....>>>.>>))).]....<<<<<<...<.<<.......>>
.>.>>>>>>.........>>>>..>>>>>>.......<<.<.<.<<<<<<
...<<.......>>...>>>>>>...>>.>.>.......<<<<<..<<<<
<..<<<<<<<<<......>>>>>>>..>>.<<<.<.....>.>>>.....
>>>>>......>>>.>>....<<<<<<<....>>>.>>>>....>>..>>
>.>>>>>.............<<..<<<..<<<<<<<..............
...>>>>>>><<<<<...<<<<....<<<<<<<<<......>>>>..>>>
>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>
>>..>>>...>>
Receptor-Ligand Complex Structure
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PDB5anc Mechanism of Eif6 Release from the Nascent 60S Ribosomal Subunit
Resolution4.2 Å
Binding residue
(original residue number in PDB)		M1 S2 I3 F4 T5 P6 Q9 I10 R11 L12 T13 R19 K21 S61 K62 G63 Q64 V65 K68 Q94 V95 R100 H141 K145 N147 S149 K151 Q152 L155 C216 E219 K240
Binding residue
(residue number reindexed from 1)		M1 S2 I3 F4 T5 P6 Q9 I10 R11 L12 T13 R19 K21 S61 K62 G63 Q64 V65 K68 Q94 V95 R100 H141 K145 N147 S149 K151 Q152 L155 C216 E219 K240
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0008017 microtubule binding
GO:0019843 rRNA binding
GO:0043022 ribosome binding
Biological Process
GO:0001833 inner cell mass cell proliferation
GO:0002244 hematopoietic progenitor cell differentiation
GO:0006364 rRNA processing
GO:0007052 mitotic spindle organization
GO:0030282 bone mineralization
GO:0030595 leukocyte chemotaxis
GO:0042254 ribosome biogenesis
GO:0042256 cytosolic ribosome assembly
GO:0048539 bone marrow development
Cellular Component
GO:0000922 spindle pole
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005819 spindle
GO:0005829 cytosol
GO:0005856 cytoskeleton

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:5anc, PDBe:5anc, PDBj:5anc
PDBsum5anc
PubMed26479198
UniProtQ9Y3A5|SBDS_HUMAN Ribosome maturation protein SBDS (Gene Name=SBDS)

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