Structure of PDB 3k7r Chain J Binding Site BS01

Receptor Information
>3k7r Chain J (length=72) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AEIKHYQFNVVMTCSGCSGAVNKVLTKLEPDVSKIDISLEKQLVDVYTTL
PYDFILEKIKKTGKEVRSGKQL
Ligand information
Ligand IDCU
InChIInChI=1S/Cu/q+2
InChIKeyJPVYNHNXODAKFH-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Cu+2]
CACTVS 3.341[Cu++]
FormulaCu
NameCOPPER (II) ION
ChEMBL
DrugBankDB14552
ZINC
PDB chain3k7r Chain J Residue 74 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB3k7r Tetrathiomolybdate inhibits copper trafficking proteins through metal cluster formation.
Resolution2.28 Å
Binding residue
(original residue number in PDB)		C15 C18
Binding residue
(residue number reindexed from 1)		C14 C17
Annotation score3
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0016531 copper chaperone activity
GO:0046872 metal ion binding
Biological Process
GO:0006825 copper ion transport
GO:0006879 intracellular iron ion homeostasis
GO:0034599 cellular response to oxidative stress
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3k7r, PDBe:3k7r, PDBj:3k7r
PDBsum3k7r
PubMed19965379
UniProtP38636|ATX1_YEAST Copper chaperone ATX1 (Gene Name=ATX1)

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