Structure of PDB 1dx5 Chain J Binding Site BS01

Receptor Information
>1dx5 Chain J (length=118) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VEPVDPCFRANCEYQCQPLDQTSYLCVCAEGFAPIPHEPHRCQMFCNQTA
CPADCDPNTQASCECPEGYILDDGFICTDIDECENGGFCSGVCHNLPGTF
ECICGPDSALAGQIGTDC
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain1dx5 Chain J Residue 502 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB1dx5 Structural Basis for the Anticoagulant Activity of the Thrombin-Thrombomodulin Complex
Resolution2.3 Å
Binding residue
(original residue number in PDB)		D423 I424 E426 N439 L440 T443
Binding residue
(residue number reindexed from 1)		D79 I80 E82 N95 L96 T99
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0004888 transmembrane signaling receptor activity
GO:0005509 calcium ion binding
Cellular Component
GO:0016020 membrane

View graph for
Molecular Function
View graph for
Cellular Component
External links
PDB RCSB:1dx5, PDBe:1dx5, PDBj:1dx5
PDBsum1dx5
PubMed10761923
UniProtP07204|TRBM_HUMAN Thrombomodulin (Gene Name=THBD)

[Back to BioLiP]