Structure of PDB 1avf Chain J Binding Site BS01

Receptor Information
>1avf Chain J (length=322) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VTYEPMAYMDAAYFGEISIGTPPQNFLVLFDTGSSNLWVPSVYCQSQACT
SHSRFNPSESSTYSTNGQTFSLQYGSGSLTGFFGYDTLTVQSIQVPNQEF
GLSENEPGTNFVYAQFDGIMGLAYPALSVDEATTAMQGMVQEGALTSPVF
SVYLSGGAVVFGGVDSSLYTGQIYWAPVTQELYWQIGIEEFLIGGQASGW
CSEGCQAIVDTGTSLLTVPQQYMSALLQATGAQEDEYGQFLVNCNSIQNL
PSLTFIINGVEFPLPPSSYILSNNGYCTVGVEPTYLSSQNGQPLWILGDV
FLRSYYSVYDLGNNRVGFATAA
Ligand information
>1avf Chain Q (length=22) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
AVVKVPLKKFKSIRETMKEKGL
Receptor-Ligand Complex Structure
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PDB1avf Structural characterization of activation 'intermediate 2' on the pathway to human gastricsin.
Resolution2.36 Å
Binding residue
(original residue number in PDB)		M7 M10 D11 A12 A13 Y14 F15 G16 L28 Q92 I94 N111 Y114 A115 Q116 A145 L146 T147 G163 G164 A165 V166 V167 F168 G169
Binding residue
(residue number reindexed from 1)		M6 M9 D10 A11 A12 Y13 F14 G15 L27 Q91 I93 N110 Y113 A114 Q115 A144 L145 T146 G156 G157 A158 V159 V160 F161 G162
Enzymatic activity
Enzyme Commision number 3.4.23.3: gastricsin.
Gene Ontology
Molecular Function
GO:0004190 aspartic-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:1avf, PDBe:1avf, PDBj:1avf
PDBsum1avf
PubMed9406551
UniProtP20142|PEPC_HUMAN Gastricsin (Gene Name=PGC)

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