Structure of PDB 7a5i Chain I3 Binding Site BS01

Receptor Information
>7a5i Chain I3 (length=158) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SKAVTRHRRVMHFQRQKLMAVTEYIPPKPAIHPSCLPGLIRLLRREIAAV
FQDNRMIAVCQNVALSAEDKLLMRHQLRKHKILMKVFPNQVLKPFLEDSK
YQNLLPLFVGHNMLLVSEEPKVKEMVRILRTVPFLPLLGGCIDDTILSRQ
GFINYSKL
Ligand information
>7a5i Chain A3 (length=1485) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gcuaaaccuagccccaaacccacuccaccuuacuaccagcaaccuuagcc
aaaccauuuacauaaaguauaggcgauagaaauuguggcgcaauagauau
aguaccgcaagggaaagaugaaaaauuauaaccaagcauaauauagcaag
gacuaaccccuauaccuucugcauaaugaauuaacuagaaauaacuuugc
aaggagagccaaagcuaagacccccgaaaccagacgagcuaccuaagaac
agcuaagagcacacccgucuauguagcaaaauagugggaagauuuauagg
uagaggcgacaaaccuaccgagccuggugauagcugguuguccaagauag
aaucuuaguucaacuuuaaauuugcccacagaaccaaauccccuuguaaa
uuuaacuguuaguccaaagaggaacagcucuuuggacacuaggaaaaaac
cuuguagagagaguaaaaaauuuaacacccauaguaggccuaaaagcagc
caccaauuaagaaagcguucaagcucaacacccacuaccuaaaaaauccc
aaacauauaacugaacuccucacacccaauuggaccaaucuaucacccua
uagaagaacuaauguuaguauaaguaacaugaaaacauucuccuccgcau
aagccugcgucagaucacacugacaauuaacagcccaauaucuacaauca
accaacaagucauuauuacccucacugucaacccaacacaggcaugcuca
uaaggaaagguuaaaaaaaguaaaaggaacucggcaaaucuuaccccgcc
uguuuaccaaaaacaucaccucuagcaucaccaguauuagaggcaccgcc
ugcccagugacacauguuuaacggccgcgguacccuaaccgugcaaaggu
agcauaaucacuuguuccuuaaauagggaccuguaugaauggcuccacga
ggguucagcugucucuuacuuuuaaccagugaaauugaccugcccgugaa
gaggcgggcauaacacagcaagacgagaagacccuauggagcuuuaauuu
auuaaugcaaacaguaaccugcauuaaaaauuucgguuggggcgaccucg
gagcagaacccaaccuccgagcaguacaugcuaagacuucaccagucaaa
gcgaaccucaauugauccaauaacuugaccaacggaacaaguuacccuag
ggauaacagcgcaauccuauucuagaguccauaucaacaauaggguuuac
gaccucgauguuggaucaggacaucccgauggugcagccgcuauuaaagg
uucguuuguucaacgauuaaaguccuacgugaucugaguucagaccggag
uaauccaggucgguuucuaucuacuuuauuccucccuguacgaaaggaca
agagaaauaaggccuacuucacaaagcgccuucccccguaaaugauauca
ucucaacuuagauacccacacccaagaacaggguu
<<<.......<<<<....................................
<......>.....<.....<<.....>>....>...>>.>>.........
....<<....>>......................>>>...........<<
<.......>>>...<.<........>.>.<<<<<<.........<<<.<<
..<<....>>...>>.>>>...<<.<..<<<<<.<.....<<<<<.<<<.
.<<<...>>>...<<<..<<<<........>>>>.>>>....>>>.>>>>
>...<<.......>>......>.>>>>...>..>.>>..<<<<<<....<
<<<....>>>><<<.<<<<<<<<<<.....<<......>>.....>>>>>
>>>>>..>>>.<<<<<<<<<<......>>>>>>>>>>...<<<......>
>>....<<<.<<<...<..............<....<<<.........>>
>....>.......<<<......>>>.........................
...........>...>>>>>>........>>>>>>...<<<<<......>
>>>>.........>>>>>>.......<<..<<<....>>><<<<..<<<<
........<<<<<......>>>>>......<<<...<<<<..........
.............>>>>.......>>>.....<<......>>.>>>>...
..>>>>..<<<<...<<<<<<<<.<<................<<<<<<..
<<<.........>>>...<<<<<<.............>>>>>>....<<<
.<<<..<<<<<....>>>..>>>>><<<<<<......>>>>>>.......
.<...........<<<<<<.....>>>>>>.....>....>>>....>>.
>>>>........>>.>>>>>>>>>>>>.>>...........<<<<<....
....>>>>>.......<<..<<<.<<......<<<<.<<<<<<..<<<<<
.<<<<<<<<..........>>>>>>>>>>>>>..<<<<.....>>>><<<
<<<...........>>>>>>..<<.....<<<..<<<<.....>>>>..>
>>....>>.........<<<....>>>............>>>>..>>>>>
>.......<<<..<.<<<<<<...<<.......>>...>>>>>>...>.>
>.>.......<<<<<.<<<<<<..<<.<<<<<<......>>>>>>...>>
.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<.
...>>>.>>>>....>>..>>>.>>..<<<.<<<................
.>>>.>>><<<<<...<<<....>>>.>>>>>......<<<.........
.......>>>.........<<<<.......>>>>.
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7a5i Elongational stalling activates mitoribosome-associated quality control.
Resolution3.7 Å
Binding residue
(original residue number in PDB)		K31 V33 R35 R38 H41 K46 A106 V125 P127 N128 G149 H150
Binding residue
(residue number reindexed from 1)		K2 V4 R6 R9 H12 K17 A67 V86 P88 N89 G110 H111
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0005515 protein binding
Biological Process
GO:0006412 translation
GO:0032543 mitochondrial translation
Cellular Component
GO:0005654 nucleoplasm
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005762 mitochondrial large ribosomal subunit
GO:0005840 ribosome
GO:1990904 ribonucleoprotein complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7a5i, PDBe:7a5i, PDBj:7a5i
PDBsum7a5i
PubMed33243891
UniProtQ7Z7H8|RM10_HUMAN Large ribosomal subunit protein uL10m (Gene Name=MRPL10)

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