Structure of PDB 6hcq Chain I3 Binding Site BS01

Receptor Information

>6hcq Chain I3 (length=205) Species: 9986 (Oryctolagus cuniculus)

GRRPARCYRYCKNKPYPKSRFCRGVPDAKIRIFDLGRKKAKVDEFPLCGH
MVSDEYEQLSSEALEAARICANKYMVKSCGKDGFHIRVRLHPFHVIRINK
MLQTGMRGAFGKPQGTVARVHIGQVIMSIRTKLQNKEHVVEALRRAKFKF
PGRQKIHISKKWGFTKFNADEFEDMVAEKRLIPDGCGVKYIPNRGPLDKW
RALHS

Ligand information

>6hcq Chain 51 (length=3635)

cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuaguc
agcggaggaaaagaaacuaaccaggauucccucaguaacggcgagugaac
agggaagagcccagcgccgaauccccgccccgcggcggggcgcgggaaau
guggcguacggaagacccacuccccggcgccggggggcccaaguccuucu
gaucgaggcccagcccguggacggugugaggccgguagcggcccccggcg
cgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaa
agcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauag
ucaacaaguaccguaagggaaaguugaaaagaacuuugaagagagaguuc
aagagggcgugaaaccguuaagagguaaacgggugggguccgcgcagucc
gcccggaggauucaacccggcggcgcgguccggccgugccggcggggcgg
aucucccgcucccgucggcgggggaccgccccccggccggcgaccggccg
ccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggac
ggcugggaaggccccggcggggaagguggcccgggggccccggguguuac
agccccgccccggcagcagcagcucgccgaaucccggggccgagggagcg
agacccgugcgccgcgcucuccccccucgggggggccgggccaccccucc
cacggcgcgaccgcucucccacccggggggcggggcggacuguccccagu
gcgccccgggcgggucgcgccgucgggcccgggggagguucucucggggc
cacgcgucccccgcgagcgcacggggucggcggcgaugucggcuacccac
ccgacccgucuugaaacacggaccaaggagucuaacacgugcgcgagucg
ggggcuacgaaagccgccguggcgcaaugaaggugaaggccggcggcgcg
ccgccggccgaggugggaucccgaggccuuccaguccgccgagggcgcac
caccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacg
uguuaggacccgaaagauggugaacuaugccugggcagggcgaagccaga
ggaaacucugguggagguccguagcgguccugacgugcgaaucggucguc
cgaccuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguu
cccuccaaaguuucccucaggauagcuggcgcucuccgcaguuuuauccg
guaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauuc
ucaaacuuuaaauggguaagaagcccggcucgcugguguggagccgggcg
uggaaugcgagugccuagugggccacuuuugguaagcagaacuggcgcug
cgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucag
accccagaaaagguguugguugauauagacagcaggaugguggccaugga
agucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacua
gcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgc
uggcagucggcagagcgagaaagagaguggcgcggacgcuacgccgcgac
gaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccgg
guggagccgccgcaggugcagaucuuggugguaguagcaaauauucaaac
gagaacuuugaaggccgaaguggagaaggguuccaugugaacagcaguug
aacaugggucagucgguccugagagaugggcgagcgccguuccgaaggga
cgggcgauggccuccguugcccucagccgaucgaaagggagucggguuca
gauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugc
gguaacgcgaccgaucccggagaagccggcgggagccccggggagaguuc
ucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagag
aggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagc
ucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgg
gccguacccauauccgcagcaggucuccaaggugaacagccucuggcaug
uuggaacaauguagguaagggaagucggcaagccggauccguaacuucgg
gauaaggauuggcucuaagggcuggcagccgacuuagaacuggugcggac
caggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcgg
cggguguugacgcgaugugauuucugcccagugcucugaaugucaaagug
aagaaauucaaugaagcgcggguaaacggcgggaguaacuaugacucucu
uaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggau
gaacgagauucccacugucccuaccuacuauccagcgaaaccacagccaa
gggaacgggcuuggcggaaucagcggggaaagaagacccuguugagcuug
acucuagucuggcacggugaagagacaugagagguguagaauaaguggga
ggcccgggccgccggugaaauaccacuacucugaucguuuuuucacugac
ccggugaggcgggggggcgagccgggcucucgcuucuggcgccaagcgcc
cggccggccgggcgcgacccgcuccggggacagugccagguggggaguuu
gacuggggcgguacaccugucaaacgguaacgcagguguccuaaggcgag
cucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuu
gaucuugauuuucaguacgaauacagaccgugaaagcggggccucacgau
ccuucugaccuuuuggguuuuaagcaggaggugucagaaaaguuaccaca
gggauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuug
auccuucgaugucggcucuuccuaucauugugaagcagaauucaccaagc
guuggauuguucacccacuaauagggaacgugagcuggguuuagaccguc
gugagacagguuaguuuuacccuacugaugauguguuguugccaugguaa
uccugcucaguacgagaggaaccgcagguucagacauuugguguaugugc
uuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacug
aacgccucuaagucagaaucccgcccaggcggaacgauagcgccggagcc
ucgguuggccucggauagccggucccccgcccgggguccggugcggagag
cccuucgucccgggaaacggggcggccggaaagggggccgcccucucgcc
cgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguaga
cgaccugcuucugggucgggguuucguacguagcagagcagcugcugcga
ucuauugaaagucagcccucgacacaaggguuugu

.........................<<<<<<.....<......>......
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..>>>.>..<<<.<<<<<....<<<..<<<..<<<<<<<<....<<<<..
....>>>>.............<<<.......>>>...>.>>>>>>>...>
>>..>>>...>>>>.>>>>.......<<<<<<<........>>>>>>>..
....<<<<..(((((.>>>>...>>>........................
..........<<....>>...............<<<......>>>.....
.............................<<<<<<<<..<<..<....<<
<<<<<<.........<<<<<<<<<<....<<<<<<<.<<....<<<<<<<
.<<<<<<<<<......>>>>>>>>>>>>>>>>...>>>>>>...>>>.>>
>>>>>>>>..........>>>.>>>>>...<<<<<<<.<<<<<<<<<<.<
<<<.........<..<<<<<<.......<<<<.<<<.>>>.>>>>.....
...>>>>>>...>............>>>>...>>>>>>>>>>.....<<.
......>>.............<<<<<<..>>>>>>...<.<<.<<<<.<<
<<<<<...<<<<<<....<..<<...>>>.<<<<<<<...<<....>>..
.>>>>>>>.>>.>>>>...>>>>.>>>...>.>>>...........>>.>
..........................>>.>>>>>....>.>>...>>>>>
>>>..<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<.
..<<<.......>>>.....>>>...<<....>>...<<<<<<<<<<..>
>>>>>>>>>..<<<<<...<<<..<<........[...>>..>>>....>
>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>
>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<...<<.......<<.
<.....>>>........>>....<<<..<..<<........>>.>.>>>.
...>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..
<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<<.
...<<<....<<<...<<<<..<<<.<<.........>.>>>>>>>.>..
>>>...>>>....>>>>>>...<<<<<<<<<.<......>>>>>>>>>>.
...>>>>>>>>>>>>.>>>..<<<<.<<<<<.....>>>>>.>>>>....
<<<......>>>...<<<<<<<...<<.(((.......<<<<<.....<<
..........<<<.<<<..<<<.....................<<.....
....>>...............<<......>>.............>>>..>
>>>>>..........))).>>...>>>>>...>>...>>>>>>><<<<<.
.<<<.....................]................>>>.>>>>
>....>>>>>>..<<<<<<<<..<<......<<<<.<<<<....>>>>>>
>>...>>.>>>>>>>.>......>>>>>><<<....<<.....<<<<<<.
......>>>>>>.<<......<<.<..<<...<<<<<<...<<.....>>
.>>>>>>....(.<<<<<<...<<....<<<....>>>............
.<<<<<.<<<...>>>.>>>>>........>>....>>>...<<<<....
....>>>>..)<<<<....<<<......<<<<<......>>>>>....<<
<....>>>......<<<<<<<...<<<<<<<<<<<<<<<<<<<<<<<..[
[[..>>>>>>.....<<<..<<<<.<<<<.....<<<.....>>>.....
>>>>>>>>...>>>......<<<<<<<.......>>>>>>>>>>>.>.>>
>>>>>>>>>>.........>>>>>>>................>>>.>>>>
.>>>..>>.....<<......>>.>.>>.<<<<.....>>>>...>>...
.<<<<.....<<<<<<..<<...............<<<<<..........
.....>>>>><<.<<<<<<<<<<<.>>>>>..>>>>>>.>>.........
...<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<....
.>>>>......>>>>>>>..<.<..<<<..<<<<<.....<<<......<
<<....>>>......>>>..>>>..>>>>><..<<.........>>...>
.......<...........<<<<<.......>>>>>.....>.....>..
>..>>.>>>>>>>.....>>..>>>>>>..>>>>>>...>>>....<<<<
<........>>>>>.....<<<<..<<<.<<......<<<<....<<<..
<<<<..<<<<<<<<..<<<.<<<<...<.<<<<..........<<<<<..
.<<<..>>>.............>>>>>.>>>>.>...>.>>.>>>>...<
<<<<.....<<<<.................................<<<<
<.<<..>>.>>>>>...>>>>..>>>>>.....>>>>>>>>...>>>>..
..<<.....>>...<<<<<<...........>>>>>>..<<...<<<<<<
<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>.
..<<.<<<<<<.......>>>>.>>>>.<<<....>>>.>>)))].....
.<<<<<<..<<<...))))).>>>>>>>>>..........>>>.....>>
>>.......<<..<<.<<<<<<...<<.......>>...>>>>>>...>>
.>.>.........<<<.<.<<<...<...<<<<<......>>>>>.....
>.<<<.........>>>......>>>...>...>>>.......<<<<<<<
....>>>.>>>>....>>..>>>.>>>>......<.<<<<....<<<..<
.<<<<<.................>>>>>.><<<<....<<<<....<<..
<.<<<.]]]..>>>....>.>>...>>>>...>>>><<<.....<<<<..
...........>>>>.....>>>.>>>.....>>>>.>.<<<<<<<..<<
<.....<<.........<<<<<....<<<..>>>...>>>>>........
>>...<<<..<<<<....<<<.<<<<<........>>>>>..>>>...>>
>>..>>>...............>>>..>>.>>>>>.<<<<<.<.......
......>....<<.<<<<<<<.<<.....<<<<.<..<<<<<.>>>>>..
>>>>>....>>....>>>>.>>>.>>..>>>>>..

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6hcq ZNF598 Is a Quality Control Sensor of Collided Ribosomes.
• Resolution: 6.5 Å
• Binding residue (original residue number in PDB): R3 R4 A6 R7 C8 K15 Y17 F22 D35 K39 K40 E63 K74 R88 R90 H92 R98 N100 M115 R116 G117 A118 F119 G120 F157 K158 D193
• Binding residue (residue number reindexed from 1): R2 R3 A5 R6 C7 K14 Y16 F21 D34 K38 K39 E62 K73 R87 R89 H91 R97 N99 M106 R107 G108 A109 F110 G111 F148 K149 D184

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0000027 ribosomal large subunit assembly
• GO:0006412 translation
• GO:0006417 regulation of translation

Cellular Component

• GO:0005737 cytoplasm
• GO:0005840 ribosome
• GO:0022625 cytosolic large ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:6hcq, PDBe:6hcq, PDBj:6hcq
• PDBsum: 6hcq
• PubMed: 30293783
• UniProt: B7NZQ2|RL10_RABIT Large ribosomal subunit protein uL16 (Gene Name=RPL10)