Structure of PDB 7oya Chain I2 Binding Site BS01

Receptor Information
>7oya Chain I2 (length=188) Species: 7955 (Danio rerio) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GISRDNWHKRRRTGGKRKPVHKKRKYELGRPAANTKIGPRRIHTIRVRGG
NKKYRALRLDVGNFSWGSECCTRKTRIIDVVYNASNNELVRTKTLVKNCV
VLVDSTPYRQWYESHYALPLGRSKKVQKKFTLRRKTAKISPLLEEQFLQG
KLLACISSRPGQCGRADGYVLEGKELEFYLRKIKAKKG
Ligand information
>7oya Chain 22 (length=1531) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uaccugguugauccugccaguaauauaugcuugucucaaagauuaagcca
ugcaagucuaagugcacacgagugaaacugcgaauggcucauuaaaucag
uuaugguuccuuugaucacuuggauaacuguggcaauuccagagcuaaua
caugcgcgccgagacgcgugcauuuaucaguggugacucuagauaaccuc
gggccgaucgcgcgccggcggcgacgguucauucgaaugucugcccuauc
aacuuucgaugguagguccgucgccuaccauggugaccacgggugacggg
gaaucaggguucgauuccggagagggagccugagaaacggcuaccacauc
caaggaaggcagcaggcgcgcaaauuacccauuuccgacacggagaggua
gugacgaaaaauaacaaugaauuggaaugagugcaucccaaacccauggg
cgaggacccauuggagggcaagucuggugccagcagccgcgguaauucca
gcuccaauagcguaugcuaacguugcugcaguuaaaaagcucguaguugg
aucucuacuuugaaaaaauuagaguguucaaggcagggccccccauugaa
uaccccagcuaggaauaauggaauaggaccccggggccaugaucgagagg
gacggccgggggcauucguauugcgccgcuagaggugaaauucuuggacc
ggcgcaagacggaccggagcgaaagcguuugccaagaacguuuucauuaa
ucaagaacgaaagucggagguucgaagacgaucagauaccgucguaguuc
cgaccguaaacgaugccgacccgcgauccggcggcguuugacccgccggg
cagcguugcgggaaaccacgagucucugggcuccggggggaguaugguug
caaagcugaaacuuaaaggaauugacggaagggcaccaccaggaguggag
ccugcggcuuaauuugacucaacacggggaaccucacccggcccggacac
ggaaaggauugacagauugacggcucuuucucgauucugugggugguggu
gcauggccguucguaguugguggagcgauuugucugguugauuccgauaa
cgaacgagacucuggcaugcuaacuaguuacgcggccgucggcguaacuu
cuuagagggacaaguggcguucagccacgcgagacugagcaauaacaggu
cugugaugcccuuagauguccggggcugcacgcgcgccacaaugggcgga
ucaacguguccugcgccgacaggcgcggguaacccguugaaccccgcccg
ugauggggaccgauugaaacuauuucccgagaacgaggaauucccaguaa
gcgcaggucaucagcuugcguugauuaagucccugcccuuuguacacacc
gcccgucgcuacuaccgauugagcggcucagugagguccucggaucgcga
gaagacgaucgaacucggucguuuagaggaaguaaaagucguaacaaggu
uuccguaggugaaccugcggaaggaucauua
...<<<<<.[.((((>>>>><<.<<<<<<<...<.<<..<......<<<.
<<<..<<....<<.............>>.>>......<<........<<<
.<<<..<<....<<<.....<<.....<<.<<<.....>>>.>>......
>>....<<<......>>>.<<..<<<<<...<......>..>>>>>....
..>>...<<<<.<<<..>>>>>>>....>>>...>>>>>.>>>.<<<...
.<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.
<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<
....>>.>...>>>>>>.........<<<....<<<<...>>>>..>>>.
.>...>>.>.....<<<....>>>......<<.<<<.........>>>.>
>.........<<<<<((......<<<<.....<<..))>>.......>>>
>.>>>>>..>>>>>>>.>>.........<.<((.....<.<<...<<<.<
<....<<<<<.<.......<<...<.......>...<<....>>......
>>......>.>>>..>>.........<.<<<..>>>.>....>>....<<
<<<<..<...<<<<..<<..<<<<<<<<...<<<......>>>......>
>>>>>>>..>>.......<<....>>...>>>>..>..>>>.>>>...>>
>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>
>>>>..........<<<.<<.<<<..<<<<<<<<.<<<.>>>>>>>>>>>
..>>>....<<..))>>....>>.....>>>.>.>.<<<......<<<..
....>>>....>>>..)))).]<<<<<.<<<<<<...<...<<<<<...<
<.<<<<<<......<<........>>..........<<<<<.<.......
.<........<<..<<........>>..>>.......>....<.<<.<<<
..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>
>.>>>....<<<.......<<<<..<<<<<<<<<<<.>>>.>>>>>>>>.
.>>>>........<<<<<.....>>>>>........>>>....>>>.>>>
.....>>>>>>>>....>.>>>>>...>>.>>>>.>>......<<<<<<.
.......<.<<<<<<<<....>>>>>>>>....>.........>>>>>>.
..........<<<...........>>..>..........>>>>>.....<
<<<<<<<.......>>>>>>>>.......>....>>>>>>>>>.>>....
<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<..>>
...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....
<<<<<<<<<<..>>>>>>>>>>.........
Receptor-Ligand Complex Structure
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PDB7oya A molecular network of conserved factors keeps ribosomes dormant in the egg.
Resolution3.2 Å
Binding residue
(original residue number in PDB)
G2 I3 R5 D6 N7 H9 K10 R11 R12 T14 G16 K19 V21 H22 K23 K24 R25 K26 Y27 L29 R31 A34 R42 I43 H44 T45 R47 V48 R49 G50 K53 K54 Y55 R56 L58 R59 N64 S66 T73 R74 K75 S86 K98 N99 V145 K148 R152 S176 Q181 C182 R184 D186 G187
Binding residue
(residue number reindexed from 1)
G1 I2 R4 D5 N6 H8 K9 R10 R11 T13 G15 K18 V20 H21 K22 K23 R24 K25 Y26 L28 R30 A33 R41 I42 H43 T44 R46 V47 R48 G49 K52 K53 Y54 R55 L57 R58 N63 S65 T72 R73 K74 S85 K97 N98 V126 K129 R133 S157 Q162 C163 R165 D167 G168
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
Biological Process
GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0006412 translation
GO:0042274 ribosomal small subunit biogenesis
GO:0043009 chordate embryonic development
GO:0051726 regulation of cell cycle
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005840 ribosome
GO:0016020 membrane
GO:0022627 cytosolic small ribosomal subunit
GO:0032040 small-subunit processome
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function

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Biological Process

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Cellular Component
External links
PDB RCSB:7oya, PDBe:7oya, PDBj:7oya
PDBsum7oya
PubMed36653451
UniProtP62247|RS8_DANRE Small ribosomal subunit protein eS8 (Gene Name=rps8)

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