Structure of PDB 9ft0 Chain I Binding Site BS01

Receptor Information

>9ft0 Chain I (length=204) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

SDPSSINGGIVVAMTGKDCVAIACDLRLGSQSLGVSNKFEKIFHYGHVFL
GITGLATDVTTLNEMFRYKTNLYKLKEERAIEPETFTQLVSSSLYERRFG
PYFVGPVVAGINSKSGKPFIAGFDLIGCIDEAKDFIVSGTASDQLFGMCE
SLYEPNLEPEDLFETISQALLNAADRDALSGWGAVVYIIKKDEVVKRYLK
MRQD

Ligand information

Ligand ID

InChI

InChI=1S/Mg/q+2

InChIKey

JLVVSXFLKOJNIY-UHFFFAOYSA-N

SMILES

Software	SMILES
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Mg+2]
CACTVS 3.341	[Mg++]

Formula

Name

MAGNESIUM ION

PDB chain

9ft0 Chain I Residue 301 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	9ft0 Structure-based design of peptide epoxyketones selectively targeting the three human immunoproteasome active sites
Resolution	2.75 Å
Binding residue (original residue number in PDB)	A174 D177 S180
Binding residue (residue number reindexed from 1)	A174 D177 S180
Annotation score	4

Gene Ontology

	Molecular Function
GO:0005515	protein binding
GO:0061133	endopeptidase activator activity

	Biological Process
GO:0010499	proteasomal ubiquitin-independent protein catabolic process
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process

	Cellular Component
GO:0000502	proteasome complex
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0019774	proteasome core complex, beta-subunit complex

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External links

PDB	RCSB:9ft0, PDBe:9ft0, PDBj:9ft0
PDBsum	9ft0
PubMed
UniProt	P25451\|PSB3_YEAST Proteasome subunit beta type-3 (Gene Name=PUP3)

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