Structure of PDB 8y6o Chain I Binding Site BS01

Receptor Information
>8y6o Chain I (length=597) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EAKPKFLSKAEREAEALKRRQQEVEERQRMLEEERKKRKQFQDLGRKDKS
KELHAIKERYLRKFVFEWDASEDTSIDYNPLYKERHQVQLLGRGFIAGID
LKQQKREQSRFYGDLMEKRRTLEEKEQEEARLRKLRKKEAKQRWDDRHWS
QKKLDEMTDRDWRIFREDYSITTKGGKIPNPIRSWKDSSLPPHILEVIDK
CGYKEPTPIQRQAIPIGLQNRDIIGVAETGSGKTAAFLIPLLVWITTLPK
IDRIEESDQGPYAIILAPTRELAQQIEEETIKFGKPLGIRTVAVIGGISR
EDQGFRLRMGCEIVIATPGRLIDVLENRYLVLSRCTYVVLDEADRMIDMG
FEPDVQKILEHMPVSNQKPDTDEAEDPEKMLANFESGKHKYRQTVMFTAT
MPPAVERLARSYLRRPAVVYIGAGKPHERVEQKVFLMSESEKRKKLLAIL
EQGFDPPIIIFVNQKKGCDVLAKSLEKMGYNACTLHGGKGQEQREFALSN
LKAGAKDILVATDVAGRGIDIQDVSMVVNYDMAKNIEDYIHRIGRTGRAG
KSGVAITFLTKEDSAVFYELKQAILESPVSSCPPELANHPDAQHKPG
Ligand information
Receptor-Ligand Complex Structure
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PDB8y6o Structural basis of U12-type intron engagement by the fully assembled human minor spliceosome
Resolution3.38 Å
Binding residue
(original residue number in PDB)		K675 K686
Binding residue
(residue number reindexed from 1)		K466 K477
Enzymatic activity
Enzyme Commision number 3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0003724 RNA helicase activity
GO:0003729 mRNA binding
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
Biological Process
GO:0000354 cis assembly of pre-catalytic spliceosome
GO:0000375 RNA splicing, via transesterification reactions
GO:0000398 mRNA splicing, via spliceosome
GO:0006397 mRNA processing
GO:0008380 RNA splicing
GO:0062176 R-loop processing
Cellular Component
GO:0000785 chromatin
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005681 spliceosomal complex
GO:0005682 U5 snRNP
GO:0005694 chromosome
GO:0005730 nucleolus
GO:0046540 U4/U6 x U5 tri-snRNP complex
GO:0070062 extracellular exosome
GO:0071013 catalytic step 2 spliceosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8y6o, PDBe:8y6o, PDBj:8y6o
PDBsum8y6o
PubMed38484052
UniProtQ9BUQ8|DDX23_HUMAN Probable ATP-dependent RNA helicase DDX23 (Gene Name=DDX23)

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