Structure of PDB 8xgc Chain I Binding Site BS01

Receptor Information
>8xgc Chain I (length=745) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NAADFSLTVLRARIALLATAIGGPDYTSQIDPPPYKLGDDCLACLKDLKR
WFKLVDDQQKRWDVAMAVAEYRILTDDLLPILIDWENKCSLAAKLAKNNP
DHEEFRNKAYYDKIALNCLQLLVLMTWPLIVTEQSSSNQITLYGELKKHQ
LVYKKTILSMESGKVLRAAIRLALDVIKIDRLSRTPRDNMVLKLVLNFFR
NVIAIEPGEFTINTKKSMPKKGITSIDTLPPNVSMDDISLNTVISSFHKN
KVFGFLLTLTSSLSKEFDQDFINIPLLEIMFYFTKDVNQELLFPRTSAGF
ELSKLLQKEHQMRKNVIKHTSARHSRFGGLLSIQTPDKTRLTVSGSQALV
DEKIALQKLDDSKKWNKRIIKKHQSVAAEGLPNSLLNSQTGKAIFFTESN
GKHFKEFINNFIDSGFNILLHSVTNYFTTEQDRMVTLEQVEYLLFFAWFV
KYQLLRSKIDNSADIKQVSEALKEVTFILVSSLLRSAYDLKNWTVTHAGM
IAFNELLNLVSRTKAAQETDIEFIVSRLFSDERIQLLSNLPKIGSKYSLQ
FMKSCIELTHSVLKVLEQYSDDKTLVIEGKSRRQKKFNISEGDITKLIEE
ENVDRDEALDILTSSLRSIEVNFQKVQANYMTEPVIETYINFLERFRELE
DDSIKKVFSFFHRVFVQAKEQALLFRFDLIILLREMLSPDGLDRMSRSRK
YVSQFSDYFLARLKKRLKKSPAWFVGLLFPPLHNSEVGFYQRYGE
Ligand information
>8xgc Chain K (length=20) Species: 4932 (Saccharomyces cerevisiae) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
KFFSKESFLADFDDSSSNED
Receptor-Ligand Complex Structure
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PDB8xgc Parental histone transfer caught at the replication fork.
Resolution3.7 Å
Binding residue
(original residue number in PDB)		K104 K107 R181 L184 K261 F265 T268 S271 N443 S447
Binding residue
(residue number reindexed from 1)		K94 K97 R171 L174 K251 F255 T258 S261 N410 S414
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003674 molecular_function
GO:0003677 DNA binding
GO:0005515 protein binding
Biological Process
GO:0000076 DNA replication checkpoint signaling
GO:0006260 DNA replication
GO:0006281 DNA repair
GO:0007064 mitotic sister chromatid cohesion
GO:0008156 negative regulation of DNA replication
GO:0031297 replication fork processing
GO:0043111 replication fork arrest
GO:0043570 maintenance of DNA repeat elements
GO:0051321 meiotic cell cycle
Cellular Component
GO:0005634 nucleus
GO:0005829 cytosol
GO:0031298 replication fork protection complex
GO:0043596 nuclear replication fork

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8xgc, PDBe:8xgc, PDBj:8xgc
PDBsum8xgc
PubMed38448592
UniProtP53840|TOF1_YEAST Topoisomerase 1-associated factor 1 (Gene Name=TOF1)

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