Structure of PDB 8x15 Chain I Binding Site BS01

Receptor Information
>8x15 Chain I (length=792) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KSHAEIAEQAKHEAEIETRIAELRKEGFWSLKRLPKVPEPPRPKGHWDYL
CEEMQWLSADFAQERRWKRGVARKVVRMVIRHHEEQRQKEERARREEQAK
LRRIASTMAKDVRQFWSNVEKVVQFKQQSRLEEKRKKALDLHLDFIVGQT
EKYSDLLSQSLNTQVKTPIPLLLRGQLREYQHIGLDWLVTMYEKKLNGIL
ADEMGLGKTIQTISLLAHLACEKGNWGPHLIIVPTSVMLNWEMELKRWCP
SFKILTYYGAQKERKLKRQGWTKPNAFHVCITSYKLVLQDHQAFRRKNWR
YLILDEAQNIKNFKSQRWQSLLNFNSQRRLLLTGTPLQNSLMELWSLMHF
LEHVIRCRLSKRQRCLYDDFMAQTTTKETLATGHFMSVINILMQLRKVCN
HPNLFDPRPVTSPFITPGICFSTASLVLRATDVHPLQRIDMGRFDLIGLE
GRVSRYEADTFLPRHRLSRRVLLEVATAPDPPPRPKPVKMPFYLDSLEEK
RKRQRSERLERIFQLSEAHGALAPVYGTEVLDFCTLPQPVASPIGPRSPG
PSHPTFWTYTEAAHRAVLFPQQRLDQLSEIIERFIFVMPPVEAPPPSLHA
CHPPPWLAPRQAAFQEQLASELWPRARPLHRIVCNMRTQFPDLRLIQYDC
GKLQTLAVLLRQLKAEGHRVLIFTQMTRMLDVLEQFLTYHGHLYLRLDGS
TRVEQRQALMERFNADKRIFCFILSTRSGGVGVNLTGADTVVFYDSDWNP
TMDAQAQDRCHDVHIYRLISERTVEENILKKANQKRMLGDMA
Ligand information
>8x15 Chain X (length=137) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
caggatgtatatatgtgacacgtgcctggagactagggagtaatcccctt
ggcggttaaaacgcgggggacagcgcgtacgtgcgtttaagcggtgctag
agctgtctacgaccaattgagcggcctcggcaccggg
Receptor-Ligand Complex Structure
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PDB8x15 Structure of nucleosome-bound SRCAP-C in the apo state
Resolution3.2 Å
Binding residue
(original residue number in PDB)		K164 R167 E174 Q702 R705 R709 Q710 G711 W712 Q730 R737
Binding residue
(residue number reindexed from 1)		K74 R77 E84 Q261 R264 R268 Q269 G270 W271 Q289 R296
Enzymatic activity
Enzyme Commision number 3.6.4.-
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003713 transcription coactivator activity
GO:0004386 helicase activity
GO:0004402 histone acetyltransferase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
GO:0042393 histone binding
GO:0140658 ATP-dependent chromatin remodeler activity
Biological Process
GO:0006325 chromatin organization
GO:0006338 chromatin remodeling
GO:0006355 regulation of DNA-templated transcription
GO:0006357 regulation of transcription by RNA polymerase II
GO:0045893 positive regulation of DNA-templated transcription
Cellular Component
GO:0000786 nucleosome
GO:0000812 Swr1 complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005794 Golgi apparatus
GO:0016604 nuclear body
GO:0032991 protein-containing complex
GO:0048471 perinuclear region of cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8x15, PDBe:8x15, PDBj:8x15
PDBsum8x15
PubMed38331872
UniProtQ6ZRS2|SRCAP_HUMAN Helicase SRCAP (Gene Name=SRCAP)

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