Structure of PDB 8w5k Chain I Binding Site BS01

Receptor Information
>8w5k Chain I (length=307) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
HSHRQSLELVNPGTVENLNKEVSRDVFLSQYFFTGLRADLNKAFSMNPAF
QTSHTFSIGSQALPKYAFSALFANDNLFAQGNIDNDLSVSGRLNYGWDKK
NISKVNLQISDGQPTMCQLEQDYQASDFSVNVKTLNPSFSEKGEFTGVAV
ASFLQSVTPQLALGLETLYSRTDGSAPGDAGVSYLTRYVSKKQDWIFSGQ
LQANGALIASLWRKVAQNVEAGIETTLQPTVEGSTTIGAKYEYRQSVYRG
TLDSNGKVACFLERKVLPTLSVLFCGEIDHFKNDTKIGCGLQFETAGNQE
LLMLQQG
Ligand information
Ligand ID46E
InChIInChI=1S/C33H66NO8P/c1-3-5-7-9-11-13-15-17-19-21-23-25-32(35)39-29-31(30-41-43(37,38)40-28-27-34)42-33(36)26-24-22-20-18-16-14-12-10-8-6-4-2/h31H,3-30,34H2,1-2H3,(H,37,38)/t31-/m1/s1
InChIKeyNEZDNQCXEZDCBI-WJOKGBTCSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.9.2CCCCCCCCCCCCCC(=O)OC[C@H](COP(=O)(O)OCCN)OC(=O)CCCCCCCCCCCCC
OpenEye OEToolkits 1.9.2CCCCCCCCCCCCCC(=O)OCC(COP(=O)(O)OCCN)OC(=O)CCCCCCCCCCCCC
CACTVS 3.385CCCCCCCCCCCCCC(=O)OC[C@H](CO[P](O)(=O)OCCN)OC(=O)CCCCCCCCCCCCC
ACDLabs 12.01O=C(OCC(OC(=O)CCCCCCCCCCCCC)COP(=O)(OCCN)O)CCCCCCCCCCCCC
CACTVS 3.385CCCCCCCCCCCCCC(=O)OC[CH](CO[P](O)(=O)OCCN)OC(=O)CCCCCCCCCCCCC
FormulaC33 H66 N O8 P
Name(2R)-3-{[(S)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-(tetradecanoyloxy)propyl tetradecanoate
ChEMBL
DrugBank
ZINCZINC000032793028
PDB chain8w5k Chain I Residue 401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8w5k The architecture of substrate-engaged TOM-TIM23 supercomplex reveals preprotein proximity sites for mitochondrial protein translocation.
Resolution3.6 Å
Binding residue
(original residue number in PDB)		L328 R330
Binding residue
(residue number reindexed from 1)		L262 R264
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0008320 protein transmembrane transporter activity
GO:0015288 porin activity
Biological Process
GO:0006811 monoatomic ion transport
GO:0015031 protein transport
GO:0030150 protein import into mitochondrial matrix
GO:0045040 protein insertion into mitochondrial outer membrane
GO:0055085 transmembrane transport
Cellular Component
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0005742 mitochondrial outer membrane translocase complex
GO:0005758 mitochondrial intermembrane space
GO:0005829 cytosol
GO:0046930 pore complex

View graph for
Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8w5k, PDBe:8w5k, PDBj:8w5k
PDBsum8w5k
PubMed38360717
UniProtP23644|TOM40_YEAST Mitochondrial import receptor subunit TOM40 (Gene Name=TOM40)

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