Structure of PDB 8t9g Chain I Binding Site BS01

Receptor Information
>8t9g Chain I (length=605) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KRVKSEYMRLRQLKRFRRADEVKSMFSSNRQKILERTEILNQEWKQRRIQ
PVHILTSVSSLRGTRECSVTSDLDFPTQVIPLKTLNAVASVPIMYSWSPL
QQNFMVEDETVLHNIPYMGDEVLDQDGTFIEELIKNYDGKVHGDRECGFI
NDEIFVELVNALGQYSDKIFEAISSMFPDKGTAEELKEKYKELTEQQLPG
ALPPECTPNIDGPNAKSVQREQSLHSFHTLFCRRCFKYDCFLHFHATPNT
YKRKNTETALDNKPCGPQCYQHLEGAKEFAAALTPPENVEWSGAEASMFR
VLIGTYYDNFCAIARLIGTKTCRQVYEFRVKESSIIAPAPAEDVDTPPRK
KKRKHRLWAAHCRKIQLKKDGSSNHVYNYQPCDHPRQPCDSSCPCVIAQN
FCEKFCQCSSECQNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCLTCGAA
DHWDSKNVSCKNCSIQRGSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEY
CGEIISQDEADRRGKVYDKYMCSFLFNLNNDFVVDATRKGNKIRFANHSV
NPNCYAKVMMVNGDHRIGIFAKRAIQTGEELFFDYRYSQADALKYVGIER
EMEIP
Ligand information
>8t9g Chain T (length=215) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gactgtgtgcccgtcagacgctgcgccgccggcggccggagaatcccggt
gccgaggccgccctattggtcgtagacagccccagcaccgcctaaacgca
cgtacgcgccgtcccccgcgttttaaccgccaaggggattaccccccagt
ccccaggcacgtgccagatatatacatcccgtacgcacgcacatcattcg
atcggagctcccgat
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB8t9g Activation of automethylated PRC2 by dimerization on chromatin
Resolution6.2 Å
Binding residue
(original residue number in PDB)		K500 R502 L503 R566 C567 K568 A569 Q570 Q575
Binding residue
(residue number reindexed from 1)		K354 R356 L357 R420 C421 K422 A423 Q424 Q429
External links
PDB RCSB:8t9g, PDBe:8t9g, PDBj:8t9g
PDBsum8t9g
PubMed
UniProtQ15910|EZH2_HUMAN Histone-lysine N-methyltransferase EZH2 (Gene Name=EZH2)

[Back to BioLiP]