Structure of PDB 8ro2 Chain I Binding Site BS01

Receptor Information
>8ro2 Chain I (length=753) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EEDLPYEEEIMRNQFSVKCWLRYIEFKQGAPKPRLNQLYERALKLLPCSY
KLWYRYLKARRAQVKHRCVTDPAYEDVNNCHERAFVFMHKMPRLWLDYCQ
FLMDQGRVTHTRRTFDRALRALPITQHSRIWPLYLRFLRSHPLPETAVRG
YRRFLKLSPESAEEYIEYLKSSDRLDEAAQRLATVVNDERFVSKAGKSNY
QLWHELCDLISQNPDKVQSLNVDAIIRGGLTRFTDQLGKLWCSLADYYIR
SGHFEKARDVYEEAIRTVMTVRDFTQVFDSYAQFEESMIAAKMETASELG
REEEDDVDLELRLARFEQLISRRPLLLNSVLLRQNPHHVHEWHKRVALHQ
GRPREIINTYTEAVQTVDPFKATGKPHTLWVAFAKFYEDNGQLDDARVIL
EKATKVNFKQVDDLASVWCQCGELELRHENYDEALRLLRKATALPARRAE
YFDGSEPVQNRVYKSLKVWSMLADLEESLGTFQSTKAVYDRILDLRIATP
QIVINYAMFLEEHKYFEESFKAYERGISLFKWPNVSDIWSTYLTKFIARY
GGRKLERARDLFEQALDGCPPKYAKTLYLLYAQLEEEWGLARHAMAVYER
ATRAVEPAQQYDMFNIYIKRAAEIYGVTHTRGIYQKAIEVLSDEHAREMC
LRFADMECKLGEIDRARAIYSFCSQICDPRTTGAFWQTWKDFEVRHGNED
TIKEMLRIRRSVQATYNTQAQSKILFVRSDASREELAELAQQVNPEEIQL
GED
Ligand information
>8ro2 Chain z (length=25) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
PDYQQQCHEMAERLEDSVLKGMQAA
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8ro2 Mechanism for the initiation of spliceosome disassembly.
Resolution3.5 Å
Binding residue
(original residue number in PDB)		D226 K257 C260 I267 R268 R290 Q294
Binding residue
(residue number reindexed from 1)		D208 K239 C242 I249 R250 R272 Q276
External links
PDB RCSB:8ro2, PDBe:8ro2, PDBj:8ro2
PDBsum8ro2
PubMed38925148
UniProtQ9HCS7|SYF1_HUMAN Pre-mRNA-splicing factor SYF1 (Gene Name=XAB2)

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