Structure of PDB 8qbm Chain I Binding Site BS01

Receptor Information
>8qbm Chain I (length=309) Species: 469008 (Escherichia coli BL21(DE3)) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SAEYLNTFRLRNLGLPVMNNLHDMSKATRISVETLRLLIYTADFRYRIYT
VEKKGPEKRMRTIYQPSRELKALQGWVLRNILDKLSSSPFSIGFEKHQSI
LNNATPHIGANFILNIDLEDFFPSLTANKVFGVFHSLGYNRLISSVLTKI
CCYKNLLPQGAPSSPKLANLICSKLDYRIQGYAGSRGLIYTRYADDLTLS
AQSMKKVVKARDFLFSIIPSEGLVINSKKTCISGPRSQRKVTGLVISQEK
VGIGREKYKEIRAKIHHIFCGKSSEIEHVRGWLSFILSVDSKSHRRLITY
ISKLEKKYG
Ligand information
>8qbm Chain O (length=61) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ugcgcacccuuagcgagaggccucuggauguugcggcauccugcauugaa
ucugaguuacu
...............<<<<..>>>><<<<<<<..>>>>>>>.........
...........
Receptor-Ligand Complex Structure
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PDB8qbm Retron-Eco1 assembles NAD + -hydrolyzing filaments that provide immunity against bacteriophages.
Resolution3.09 Å
Binding residue
(original residue number in PDB)		K56 F96 E97 H99 Q100 S101 G162 A163 P164 T232 C233 I234 R238 S239 Q240 R257 K261 A265 G283 S286 S290
Binding residue
(residue number reindexed from 1)		K54 F94 E95 H97 Q98 S99 G160 A161 P162 T230 C231 I232 R236 S237 Q238 R255 K259 A263 G281 S284 S288
Enzymatic activity
Enzyme Commision number 2.7.7.49: RNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003964 RNA-directed DNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0006974 DNA damage response
GO:0051607 defense response to virus

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Molecular Function
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Biological Process
External links
PDB RCSB:8qbm, PDBe:8qbm, PDBj:8qbm
PDBsum8qbm
PubMed38788717
UniProtP23070|RT86_ECOLX Retron Ec86 reverse transcriptase (Gene Name=ret)

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