Structure of PDB 8q7e Chain I Binding Site BS01

Receptor Information
>8q7e Chain I (length=924) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LMVPLRLQAYPEELIRQRHDGHPEYLIRWSVLKCEHILMWLSAPEVYANC
PGLLDEVAMGEMEADVQALVRRAARQLAESGTPSLTAAVLHTIHVLSAYA
SIGPLTGVFRETGALDLLMHMLCNPEPQIRRSAGKMLQALAAHDAGSRAH
VLLSLSQQHMDFDSRYTLLELFAETTSSEEHCMAFEGIHLPQIPGKLLFS
LVKRYLCVTSLLDQLNSRGQRELEFSMAVGNLISELVRSMGWARPTRSIF
QPLYPLPYLQPTQAEWWELLFFIKKLDLCEQQPIFQNLWKNLGEISVSVE
MAESLLQVLSSRFEGSTLNDLLNSQIYTKYLSVLRVITRLLDFPEAMVLP
WHEVLEPCLNCLSDSEIVQELTCFLHRLASHKDYAVVLCCLGAVTECEKY
AQLYSNLTSSILAGCIQMVLGQIEDHRRTHQPINIPFFDVFLRHLCQFWP
LFREQLCRRTCLFYTIRAQAWSRDIAEDHRRLLQLCPRLNRVLRHEQNFA
DRFLPDDEAAQALGKTCWEALVSPLVQNITSPDAEGVSALGWLLDQYLEQ
RETSRNPLSRAASFASRVRRLCHLLVHVEPPSSSLRNITQCWLSVVQEQV
SRFLAAAWRAPDFVPRYCKLYEHLQRAGSELFGPRAAFMLALRSGFSGAL
LQQSFLTAAHMSEQFARYIDQQIQGGLIGGAPGVEMLGQLQRHLEPIMVL
SGLELATTFEHFYQHYMADRLLSFSWLEGAVLEQIGLCFPNRLPQLMLQS
LSTSEELQRQFHLFQLQRLDKLFLEQEDEPSPAISILVLSPRCWPVSPLC
YLYHPRKCLPTEFCDALDRFSSFYSQSQNHRRLQWTWLGRAELQFGKQIL
HVSTVQMWLLLKFNQTEEVSVETLLKDSDLSPELLLQALVPLTSGNGPLT
LHEGVLRLHEALWLIPPQAYLNVE
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8q7e Noncanonical assembly, neddylation and chimeric cullin RING/RBR ubiquitylation by the 1.8 MDa CUL9 E3 ligase complex
Resolution4.4 Å
Binding residue
(original residue number in PDB)		A1694 S1696 L1698 L1700 Q1753 W1754 T1755 R1759 E1761
Binding residue
(residue number reindexed from 1)		A783 S785 L787 L789 Q834 W835 T836 R840 E842
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008270 zinc ion binding
GO:0016740 transferase activity
GO:0031625 ubiquitin protein ligase binding
GO:0046872 metal ion binding
GO:0061630 ubiquitin protein ligase activity
Biological Process
GO:0000226 microtubule cytoskeleton organization
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0007088 regulation of mitotic nuclear division
GO:0016567 protein ubiquitination
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0031461 cullin-RING ubiquitin ligase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8q7e, PDBe:8q7e, PDBj:8q7e
PDBsum8q7e
PubMed38605244
UniProtQ8IWT3|CUL9_HUMAN Cullin-9 (Gene Name=CUL9)

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