Structure of PDB 8je1 Chain I Binding Site BS01

Receptor Information
>8je1 Chain I (length=223) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
THKDLLRFAQVFSQMIHLNDIECVLRCSVLEIEQSMNRVKNISDADVHNA
MDNYECNLYTFLYLVCISTSEEDQCKINKQIYNLIHLDPRTREGFTLLHL
AVNSFPNALVTKLLLDCGAEVNAVDNEGNSALHIIVQYNRPISDFLTLHS
IIISLVEAGAHTDMTNKQNKTPLDKSTTGVSEILLKTQMKMSLKCLAARA
VRANDINYQDQIPRTLEEFVGFH
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain8je1 Chain I Residue 701 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8je1 Structural insights into the ubiquitylation strategy of the oligomeric CRL2 FEM1B E3 ubiquitin ligase.
Resolution3.95 Å
Binding residue
(original residue number in PDB)		D567 H627
Binding residue
(residue number reindexed from 1)		D163 H223
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005123 death receptor binding
GO:0005515 protein binding
GO:0046872 metal ion binding
GO:1990756 ubiquitin-like ligase-substrate adaptor activity
Biological Process
GO:0002070 epithelial cell maturation
GO:0006915 apoptotic process
GO:0016567 protein ubiquitination
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0051438 regulation of ubiquitin-protein transferase activity
GO:0060442 branching involved in prostate gland morphogenesis
GO:0060743 epithelial cell maturation involved in prostate gland development
GO:0140627 ubiquitin-dependent protein catabolic process via the C-end degron rule pathway
GO:1902041 regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:2000001 regulation of DNA damage checkpoint
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0031462 Cul2-RING ubiquitin ligase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8je1, PDBe:8je1, PDBj:8je1
PDBsum8je1
PubMed38360992
UniProtQ9UK73|FEM1B_HUMAN Protein fem-1 homolog B (Gene Name=FEM1B)

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