Structure of PDB 8gsv Chain I Binding Site BS01

Receptor Information
>8gsv Chain I (length=155) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MSEEQVAQDTEEVFRSYVFYRHQQEQEAADPEMVTLPLQPSSTMGQVGRQ
LAIIGDDINRRYDSEFQTMLQHLQPTAENAYEYFTKIATSLFESGINWGR
VVALLGFGYRLALHVYQHGLTGFLGQVTRFVVDFMLHHSIARWIAQRGGW
VAALN
Ligand information
>8gsv Chain J (length=23) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
EEIIHKLAMQLRHIGDNIDHRMV
Receptor-Ligand Complex Structure
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PDB8gsv Structural basis for proapoptotic activation of Bak by the noncanonical BH3-only protein Pxt1.
Resolution2.2 Å
Binding residue
(original residue number in PDB)		I85 Y89 F93 M96 K113 I114 S117 L118 S121 N124 G126 R127 A130 F134
Binding residue
(residue number reindexed from 1)		I58 Y62 F66 M69 K86 I87 S90 L91 S94 N97 G99 R100 A103 F107
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Biological Process
GO:0042981 regulation of apoptotic process

View graph for
Biological Process
External links
PDB RCSB:8gsv, PDBe:8gsv, PDBj:8gsv
PDBsum8gsv
PubMed37315086
UniProtQ16611|BAK_HUMAN Bcl-2 homologous antagonist/killer (Gene Name=BAK1)

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