Structure of PDB 8dh4 Chain I Binding Site BS01

Receptor Information
>8dh4 Chain I (length=821) Species: 10760 (Escherichia phage T7) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TINIAKNDFSDIELAAIPFNTLADHYGERLAREQLALEHESYEMGEARFR
KMFERQLKAGEVADNAAAKPLITTLLPKMIARINDWFEEVKAKRGKRPTA
FQFLQEIKPEAVAYITIKTTLACLTSADNTTVQAVASAIGRAIEDEARFG
RIRDLEAKHFKKNVEEQLNKRVGHVYKKAFMQVVEADMLSKGLLGGEAWS
SWHKEDSIHVGVRCIEMLIESTGMVSLHLAPEYAEAIATRAGALAGISPM
FQPCVVPPKPWTGITGGGYWANGRRPLALVRTHSKKALMRYEDVYMPEVY
KAINIAQNTAWKINKKVLAVANVITKWKHCPVEDIPTAWKRAAAAVYRKD
KARKSRRISLEFMLEQANKFANHKAIWFPYNMDWRGRVYAVSMFNPQGND
MTKGLLTLAKGKPIGKEGYYWLKIHGANCAGVDKVPFPERIKFIEENHEN
IMACAKSPLENTWWAEQDSPFCFLAFCFEYAGVQHHGLSYNCSLPLAFDG
SCSGIQHFSAMLRDEVGGRAVNLLPSETVQDIYGIVAKKVNEILQADAIN
GTDNEVKVKLGTKALAGQWLAYGVTRSVTKRSVMTLAYGSKEFGFRQQVL
EDTIQPAIDSGKGLMFTQPNQAAGYMAKLIWESVSVTVVAAVEAMNWLKS
AAKLLAAEVKDKKTGEILRKRCAVHWVTPDGFPVWQEYKKPIQTRLNLMF
LGQDSEIDAHKQESGIAPNFVHSQDGSHLRKTVVWAHEKYGIESFALIHD
SFGTIPADAANLFKAVRETMVDTYESCDVLADFYDQFADQLHESQLDKMP
ALPAKGNLNLRDILESDFAFA
Ligand information
Receptor-Ligand Complex Structure
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PDB8dh4 Structural basis of transcription recognition of a hydrophobic unnatural base pair by T7 RNA polymerase.
Resolution2.8 Å
Binding residue
(original residue number in PDB)		R50 E63 R298 R423 Y427 T636 Y639 F644 Y739 P780 H784
Binding residue
(residue number reindexed from 1)		R48 E61 R281 R385 Y389 T585 Y588 F593 Y688 P718 H722
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0034062 5'-3' RNA polymerase activity
Biological Process
GO:0006351 DNA-templated transcription
GO:0019083 viral transcription
GO:0039695 DNA-templated viral transcription
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8dh4, PDBe:8dh4, PDBj:8dh4
PDBsum8dh4
PubMed36635281
UniProtP00573|RPOL_BPT7 T7 RNA polymerase (Gene Name=1)

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