Structure of PDB 8dh3 Chain I Binding Site BS01

Receptor Information
>8dh3 Chain I (length=831) Species: 10760 (Escherichia phage T7) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NIAKNDFSDIELAAIPFNTLADHYGERLAREQLALEHESYEMGEARFRKM
FERQLKAGEVADNAAAKPLITTLLPKMIARINDWFEEVKAKRGKRPTAFQ
FLQEIKPEAVAYITIKTTLACLTSADNTTVQAVASAIGRAIEDEARFGRI
RDLEAKHFKKNVEEQLNKRVGHVYKKAFMQVVEADMLSKGLLGGEAWSSW
HKEDSIHVGVRCIEMLIESTGMVSLHRQNAGVVGQDSETIELAPEYAEAI
ATRAGALAGISPMFQPCVVPPKPWTGITGGGYWANGRRPLALVRTHSKKA
LMRYEDVYMPEVYKAINIAQNTAWKINKKVLAVANVITKWKHCPVEDIPA
IWKRAAAAVYRKDKARKSRRISLEFMLEQANKFANHKAIWFPYNMDWRGR
VYAVSMFNPQGNDMTKGLLTLAKGKPIGKEGYYWLKIHGANCAGVDKVPF
PERIKFIEENHENIMACAKSPLENTWWAEQDSPFCFLAFCFEYAGVQHHG
LSYNCSLPLAFDGSCSGIQHFSAMLRDEVGGRAVNLLPSETVQDIYGIVA
KKVNEILQADAINGTDNLGTKALAGQWLAYGVTRSVTKRSVMTLAYGSKE
FGFRQQVLEDTIQPAIDSGKGLMFTQPNQAAGYMAKLIWESVSVTVVAAV
EAMNWLKSAAKLLAAEVKDKKTGEILRKRCAVHWVTPDGFPVWQEYKKPI
QTRLNLMFLGQFRDSEIDAHKQESGIAPNFVHSQDGSHLRKTVVWAHEKY
GIESFALIHDSFGTIPADAANLFKAVRETMVDTYESCDVLADFYDQFADQ
LHESQLDKMPALPAKGNLNLRDILESDFAFA
Ligand information
Receptor-Ligand Complex Structure
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PDB8dh3 Structural basis of transcription recognition of a hydrophobic unnatural base pair by T7 RNA polymerase.
Resolution3.0 Å
Binding residue
(original residue number in PDB)		R50 K164 R298 H300 W422 R423 Y427 T636 Y639 K642 F644 G645 Y739 H772 P780 H784
Binding residue
(residue number reindexed from 1)		R46 K160 R294 H296 W397 R398 Y402 T593 Y596 K599 F601 G602 Y696 H720 P728 H732
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0034062 5'-3' RNA polymerase activity
Biological Process
GO:0006351 DNA-templated transcription
GO:0019083 viral transcription
GO:0039695 DNA-templated viral transcription
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8dh3, PDBe:8dh3, PDBj:8dh3
PDBsum8dh3
PubMed36635281
UniProtP00573|RPOL_BPT7 T7 RNA polymerase (Gene Name=1)

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