Structure of PDB 8dh2 Chain I Binding Site BS01

Receptor Information
>8dh2 Chain I (length=833) Species: 10760 (Escherichia phage T7) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NTINIAKNDFSDIELAAIPFNTLADHYGERLAREQLALEHESYEMGEARF
RKMFERQLKAGEVADNAAAKPLITTLLPKMIARINDWFEEVTAFQFLQEI
KPEAVAYITIKTTLACLTSADNTTVQAVASAIGRAIEDEARFGRIRDLEA
KHFKKNVEEQLNKRVGHVYKKAFMQVVEADMLSKGLLGGEAWSSWHKEDS
IHVGVRCIEMLIESTGMVSLHTIELAPEYAEAIATRAGALAGISPMFQPC
VVPPKPWTGITGGGYWANGRRPLALVRTHSKKALMRYEDVYMPEVYKAIN
IAQNTAWKINKKVLAVANVITKWKHCPVEDIPEALTAWKRAAAAVYRKDK
ARKSRRISLEFMLEQANKFANHKAIWFPYNMDWRGRVYAVSMFNPQGNDM
TKGLLTLAKGKPIGKEGYYWLKIHGANCAGVDKVPFPERIKFIEENHENI
MACAKSPLENTWWAEQDSPFCFLAFCFEYAGVQHHGLSYNCSLPLAFDGS
CSGIQHFSAMLRDEVGGRAVNLLPSETVQDIYGIVAKKVNEILQADAING
TDNEVVTVTDENTGEISEKVKLGTKALAGQWLAYGVTRSVTKRSVMTLAY
GSKEFGFRQQVLEDTIQPAIDSGKGLMFTQPNQAAGYMAKLIWESVSVTV
VAAVEAMNWLKSAAKLLAAEVKDKKTGEILRKRCAVHWVTPDGFPVWQEY
KKPIQTRLNLMFLGQDSEIDAHKQESGIAPNFVHSQDGSHLRKTVVWAHE
KYGIESFALIHDSFGTIPADAANLFKAVRETMVDTYESCDVLADFYDQFA
DQLHESQLDKMPALPAKGNLNLRDILESDFAFA
Ligand information
Receptor-Ligand Complex Structure
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PDB8dh2 Structural basis of transcription recognition of a hydrophobic unnatural base pair by T7 RNA polymerase.
Resolution2.9 Å
Binding residue
(original residue number in PDB)		R50 R57 E63 R298 R423 Y427 T636 Y639 S641 F644 G645 Q649 Y739 P780
Binding residue
(residue number reindexed from 1)		R49 R56 E62 R277 R384 Y388 T597 Y600 S602 F605 G606 Q610 Y700 P730
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0034062 5'-3' RNA polymerase activity
Biological Process
GO:0006351 DNA-templated transcription
GO:0019083 viral transcription
GO:0039695 DNA-templated viral transcription
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8dh2, PDBe:8dh2, PDBj:8dh2
PDBsum8dh2
PubMed36635281
UniProtP00573|RPOL_BPT7 T7 RNA polymerase (Gene Name=1)

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