Structure of PDB 8d3m Chain I Binding Site BS01

Receptor Information
>8d3m Chain I (length=218) Species: 272558 (Halalkalibacterium halodurans C-125) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ASNEEDRYLMLSGLQHFQFCKRQWALIHIEQQWEENVRTIEGQHLHKKAD
QPFMKEKRGSKLTVRAMPIQSKNLQISGICDVVEFVQDSEGIELSGVSGS
YKAFPVEYKRGKPKKGDEDIVQLVAQAMCLEEMLVCRIDKGYLFYNEIKH
RVEVPITDALRDKVVQMAKEMHHYYENRHTPKVKTGPFCNNCSLQSICLP
KLMNKRSVKRYIEGRLSE
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8d3m PAM binding ensures orientational integration during Cas4-Cas1-Cas2-mediated CRISPR adaptation.
Resolution3.41 Å
Binding residue
(original residue number in PDB)		M11 S13 Q16 H17 F20 Q24 W34 R39 T40 G43 H47 G79 I80 K110 R111 N192 S194
Binding residue
(residue number reindexed from 1)		M10 S12 Q15 H16 F19 Q23 W33 R38 T39 G42 H46 G78 I79 K109 R110 N191 S193
Enzymatic activity
Enzyme Commision number 3.1.12.1: 5' to 3' exodeoxyribonuclease (nucleoside 3'-phosphate-forming).
Gene Ontology
Molecular Function
GO:0004527 exonuclease activity
GO:0046872 metal ion binding
GO:0051536 iron-sulfur cluster binding
Biological Process
GO:0051607 defense response to virus

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Molecular Function
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Biological Process
External links
PDB RCSB:8d3m, PDBe:8d3m, PDBj:8d3m
PDBsum8d3m
PubMed36272411
UniProtA0A4Y7WTW2

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