Structure of PDB 8crx Chain I Binding Site BS01

Receptor Information
>8crx Chain I (length=155) Species: 1747 (Cutibacterium acnes) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PRKGPAPKRPVMVDPVYGSPLVSQLVSKILLDGKKTVAQNIVYTALEGCR
AKNNTDPVQTLKRALDNIKPSLEVKSRRVGGATYQVPVEVKPARQTTLAM
RWLVNFSRERREKTMAERLMNEILDASNGLGASVKRREDTHKMAEANRAF
AHYRW
Ligand information
>8crx Chain A (length=1505) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
cauuggagaguuugauccuggcucaggacgaacgcuggcggcgugcuuaa
cacaugcaagucgaacggaaaggcccuuggggugcucgaguggcgaacgg
gugaguaacacgugaguaaccugcccuugacuuugggauaacuucaggaa
acuggggcuaauaccggauaggagcuccugcugcaugguggggguuggaa
aguuucggcgguuggggauggacucgcggcuuaucagcuuguuggugggg
uaguggcuuaccaaggcuuugacggguagccggccugagagggugaccgg
ccacauugggacugagauacggcccagacuccuacgggaggcagcagugg
ggaauauugcacaaugggcggaagccugaugcagcaacgccgcgugcggg
augacggccuucggguuguaaaccgcuuucgccugugacgaagcgugagu
gacgguaauggguaaagaagcaccggcuaacuacgugccagcagccgcgg
ugauacguagggugcgagcguuguccggauuuauugggcguaaagggcuc
guaggugguugaucgcgucggaaguguaaucuuggggcuuaacccugagc
gugcuuucgauacggguugacuugaggaagguaggggagaauggaauucc
ugguggagcgguggaaugcgcagauaucaggaggaacaccaguggcgaag
gcgguucucugggccuuuccugacgcugaggagcgaaagcguggggagcg
aacaggcuuagauacccugguaguccacgcuguaaacgguggguacuagg
ugugggguccauuccacggguuccgugccguagcuaacgcuuuaaguacc
ccgccuggggaguacggccgcaaggcuaaaacucaaaggaauugacgggg
ccccgcacaagcggcggagcaugcggauuaauucgaugcaacgcguagaa
ccuuaccuggguuugacauggaucgggagugcucagagaugggugugccu
cuuggucgguucacagguggugcauggcugucgucagcucgugucgugag
auguuggguuaagucccgcaacgagcgcaacccuuguucacuguugccag
cacguuaugguggggacucaguggagaccgccggggucaacucggaggaa
gguggggaugacgucaagucaucaugccccuuauguccagggcuucacgc
augcuacaauggcugguacagagaguggcgagccugugagggugagcgaa
ucucggaaagccggucucaguucggauuggggucugcaacucgaccucau
gaagucggagucgcuaguaaucgcagaucagcaacgcugcggugaauacg
uucccggggcuuguacacaccgcccgucaagucaugaaaguugguaacac
ccgaagccgguggccuaaccguugugggggagccgucgaaggugggacug
gugauuaggacuaagucguaacaagguagccguaccggaaggugcggcug
gauca
.......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....
<<<.<<<..<<<..<<.<..<<.<<<..>>>...>>>..>>>>>......
<<........<<<<<<<..<<...<<<<<<<<<<<<.....<<<<<<...
.>>>>>>......>>>>.....<<<<<<<<<<....>>>>>>>>>>....
.<<....>>>>>>>>>>..>>>>>>>>>.<<<....<<<..<<<<<<<..
.......>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>
>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.
........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<.
.....<<<<....>>>>.....>>>>...<<<<<<<......<<....>>
.......>>>>>>...>..<<<<<(((...<<<<<.....<<.)))>>..
.....>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<
...<<<.<<<<<<<.<<<<<<<<<<.....<<<<<<<.....>>>>>>>.
..>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<
<<<<<..<<<......>>>.....>>>>>>>>>...........<<....
>>.>>>>>>>..>>>>.>>>>...>>>...>>>>...<<<<<<<...<<.
..<<<<.<.....>.>>>>...>>>>>>>>>.........<<<<<<..<<
<<<<<<<<<<.<...>.>>>>>>>>>>>>..<<<..))>>>....>>>>>
>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<
<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>.....
.....<<<<<<<......<<<<<.<....<<<<<<....>>>>>>.....
......>.>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>
>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..
<<<......>>>>>....>>>>>>>.....<<<<<.....>>>>>.....
...>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>
>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>...
.>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>.
...>.....>>>>>>....<<<<<<<..........>>>>>>>......>
>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<..<<<
<....<.<<<<..<<<..<......>.>>>.>>>>.>...>>>>..>>>>
>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.
.....
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8crx Sarecycline inhibits protein translation in Cutibacterium acnes 70S ribosome using a two-site mechanism.
Resolution2.78 Å
Binding residue
(original residue number in PDB)		P2 R3 K4 A7 R10 S28 K29 I30 L31 L32 D33 G34 K35 K36 T37 V38 R78 G82 T98 R102 R109 K114 M116
Binding residue
(residue number reindexed from 1)		P1 R2 K3 A6 R9 S27 K28 I29 L30 L31 D32 G33 K34 K35 T36 V37 R77 G81 T97 R101 R108 K113 M115
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0000049 tRNA binding
GO:0003723 RNA binding
GO:0003729 mRNA binding
GO:0003735 structural constituent of ribosome
GO:0019843 rRNA binding
Biological Process
GO:0000028 ribosomal small subunit assembly
GO:0006412 translation
Cellular Component
GO:0005840 ribosome
GO:0015935 small ribosomal subunit
GO:0022627 cytosolic small ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8crx, PDBe:8crx, PDBj:8crx
PDBsum8crx
PubMed36864821
UniProtA0A2B7ITZ4

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