Structure of PDB 8c01 Chain I Binding Site BS01

Receptor Information

>8c01 Chain I (length=141) Species: 4932 (Saccharomyces cerevisiae)

GVSVRDVAAQDFINAYASFLQRQGKLEVPGYVDIVKTSSGNEMPPQDAEG
WFYKRAASVARHIYMRKQVGVGKLNKLYGGAKSRGVRPYKHIDASGSINR
KVLQALEKIGIVEISPKGGRRISENGQRDLDRIAAQTLEED

Ligand information

>8c01 Chain 2 (length=1545)

aucugguugauccugccaguagucauaugcuugucucaaagauuaagcca
ugcaugucuaaguauaagcaaauacagugaaacugcgaauggcucauuaa
aucaguuaucguuuauuugauaguuacaugguauaacugugguaauucua
gagcuaauacaugcuuaaaaucucgaagagauguauuuauuagauaaaaa
uugaugauucauaauaacuuuucgaaucgcauggccgcuggcgaugguuc
auucaaauuucugcccuaucaacuuucgaugguaggauaguggccuacca
ugguuucaacggguaacggggaauaaggguucgauuccggagagggagcc
ugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuaccc
aauccuaauucagggagguagugacaauaaauaacgauacagguuguauu
ggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagu
cuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaagu
uguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccaacg
gggccuuuuuuacuuugaaaaaauuagaguguucaaagcaggcgugcucg
aauauauuagcauggaauaauagaauaggacguuugguucuauuuuuuuc
uaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaa
uugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaag
cauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucga
agaugaucagauaccgucguagucuuaaccauaaacuaugccgacuaggg
aucgggugguguuuuuaaugacccacucggcaccuuacgagaaaucaaag
ucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaau
ugacagggcaccaccaggaguggagccugcggcuuaauuuggaaacucac
cagguccacacaauaagauugacagauugagagcucuuucuugauuuugu
ggguggugggccgguugguggagugauuugucugcuuaauugcgauaacg
aacgaccuuaaccacuaauaguggugcuagcauuugcugguuccacuucu
uagagggacuaggaaggaggggucccuuagacguucugggccgcacgcgc
gcuacacugacggagccagcgagucuaaccuuggccgagaggucuuggua
aucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcuc
uucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuac
gucccugcccuguaccuaguaccgauugaauggcuuagugaggccucagg
aucugcuuagagucagagcggagaauuuggacaaacuuggucauuuagag
gaacuaagguuuccguaggugaaccugcggaaggaucauuaaaga

..<<<<<.{.((((>>>>><<<<.<<<<<<...<.<...<......<<<.
<<<..<<....<<....<<.......>>...>>.>>......<<......
..<<<..<<..<<....<<<........<<......<<.<<.......>>
.>>......>>........<<<<<...>>>>><.<.<<<<<<......((
...........>>>>>>.>...>...<<<<..<<<.>>>.>>>>....>>
>...>>>>..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>
>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<.
.........>>>.>>.<.<<<..>>>.>...>>>>>>.........<<<.
...<<<.....>>>..>>>..>....>.>.....<<<<<<<<.>>>>>>>
>......<<..<...........>..>>.........<<<<<((....<.
<<<<.....<<..))>>.......>>>>>>>>>>..>>>>>>>>>>....
.....<<<[[.....<.<<...<<<.<<....<<<<<<.<<<<..>>>>.
>>>>>>...<<<<<.<<.......<<...<.......>..<<<..>>>..
..>>......>>.>>..>>>.........<<<..<<<<<<<<.....)).
>>>>>>>>.>>>.....>>....<<<<<<.<<...<<<<..<<..<<<<<
<.<...<<<..(...>>>......>.>>>>>>..>>.......<<....>
>...>>>>...>>>>>.>>>...>>>...>>.>....<<<<<<<...<..
.<<<<..)......>>>>...>>>>>>>>..........<<<.<<.<<<.
.<<<<<<<<.<<<......>>>>>>>>>>>..>>>...<<..]]>>...>
>.....>>>.>>>.<<<......<<<<....>>>>....>>>..)))).}
....<<<<<<..<<.<<<<<<..<<<.<<<<<<................<
<<<<.<..<<<<<.......<<.<<<........>>>.>>......>>>>
>......<<<<<.<<<.<<<<......>>...<<<......>>>...>>.
>>>..<<<<..<<.<<<..<<<<<.<<<<<<<..>>>>>>>.>>>>>...
>>>.>>..........>>>>>>>>>.......>.>>>>>...>>.>>>>.
>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>..
..>>.......>>>>>>>......<....<<<<<<..........>>>>>
>....>.....>>>>>>....<<<<<<<<.......>>>>>>>>......
>>...>>>>>>.....<<<<.<<....<<<<<<<<.<<<..<.<<..<..
.<<<<<<<.......>>>>>>>...>..>>.>..>>>.>>>>>>>>...>
>.>>>>....<<<<<<<<<....>>>>>>>>>.............

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8c01 Impact of the yeast S0/uS2-cluster ribosomal protein rpS21/eS21 on rRNA folding and the architecture of small ribosomal subunit precursors.
• Resolution: 2.7 Å
• Binding residue (original residue number in PDB): R7 Q12 K38 N43 E44 Q48 R57 S60 R63 R68 K69 K78 K84 V88 R89 H93 S97 S99 R102 Q106 G121 R122 Q129 D133
• Binding residue (residue number reindexed from 1): R5 Q10 K36 N41 E42 Q46 R55 S58 R61 R66 K67 K76 K82 V86 R87 H91 S95 S97 R100 Q104 G119 R120 Q127 D131

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0000028 ribosomal small subunit assembly
• GO:0000054 ribosomal subunit export from nucleus
• GO:0006412 translation
• GO:0042254 ribosome biogenesis
• GO:0042274 ribosomal small subunit biogenesis

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0005840 ribosome
• GO:0022627 cytosolic small ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:8c01, PDBe:8c01, PDBj:8c01
• PDBsum: 8c01
• PubMed: 36996028
• UniProt: P07280|RS19A_YEAST Small ribosomal subunit protein eS19A (Gene Name=RPS19A)