Structure of PDB 8b9z Chain I Binding Site BS01

Receptor Information
>8b9z Chain I (length=186) Species: 7227 (Drosophila melanogaster) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EPKDIVEVPKGYVYVNNKELSMEFADITDRAASTMFFGELLRGFAVTLAH
IFKEPATINYPFEKGPLSPRFRGEHALRRYPSGEERCIACKLCEAICPAQ
AITIEAEERADGSRRTTRYDIDMTKCIYCGFCQEACPVDAIVEGPNFEFS
TETHEELLYNKEKLLCNGDKWESEIASNLQADHLYR
Ligand information
Ligand IDSF4
InChIInChI=1S/4Fe.4S
InChIKeyLJBDFODJNLIPKO-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 2.0.7[S]12[Fe]3[S]4[Fe]1[S]5[Fe]2[S]3[Fe]45
CACTVS 3.385S1[Fe]S[Fe]1.S2[Fe]S[Fe]2
FormulaFe4 S4
NameIRON/SULFUR CLUSTER
ChEMBL
DrugBank
ZINC
PDB chain8b9z Chain I Residue 301 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8b9z Cryo-EM structures of mitochondrial respiratory complex I from Drosophila melanogaster.
Resolution3.28 Å
Binding residue
(original residue number in PDB)		H106 C128 P129 C157 I158 Y159 C160 G161 F162 C163 E174
Binding residue
(residue number reindexed from 1)		H75 C97 P98 C126 I127 Y128 C129 G130 F131 C132 E143
Annotation score1
Enzymatic activity
Enzyme Commision number 7.1.1.2: NADH:ubiquinone reductase (H(+)-translocating).
Gene Ontology
Molecular Function
GO:0016651 oxidoreductase activity, acting on NAD(P)H
GO:0051539 4 iron, 4 sulfur cluster binding
Cellular Component
GO:0016020 membrane

View graph for
Molecular Function
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Cellular Component
External links
PDB RCSB:8b9z, PDBe:8b9z, PDBj:8b9z
PDBsum8b9z
PubMed36622099
UniProtQ9VF27|NDUS8_DROME NADH dehydrogenase (ubiquinone) 23 kDa subunit (Gene Name=ND-23)

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