Structure of PDB 7zhs Chain I Binding Site BS01

Receptor Information
>7zhs Chain I (length=242) Species: 9606,559292 [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GEDMMHPLKVSLEDLYNGKTTKLQLSKNVLCSACSGQGGKSGAVQKCSAC
RGRGVRIMIRQLAPGMVQQMQSVCSDCNGEGEVINEKDRCKKCEGKKVIK
EVKILEVHVDKGMKHGQRITFTGEADQAPGVEPGDIVLLLQEKEHEVFQR
DGNDLHMTYKIGLVEALCGFQFTFKHLDGRQIVVKYPPGKVIEPGCVRVV
RGEGMPQYRNPFEKGDLYIKFDVQFPENNWINPDKLSELEDL
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain7zhs Chain I Residue 401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7zhs The class A Hsp40 DnaJA2 self-associates into ordered, highly dynamic tubular oligomers that productively interact with unfolded substrates and Hsc70
Resolution6.9 Å
Binding residue
(original residue number in PDB)		C73 C76 C135
Binding residue
(residue number reindexed from 1)		C31 C34 C93
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0001671 ATPase activator activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0030544 Hsp70 protein binding
GO:0031072 heat shock protein binding
GO:0031386 protein tag activity
GO:0042802 identical protein binding
GO:0044389 ubiquitin-like protein ligase binding
GO:0046872 metal ion binding
GO:0051082 unfolded protein binding
GO:0051087 protein-folding chaperone binding
Biological Process
GO:0006457 protein folding
GO:0008284 positive regulation of cell population proliferation
GO:0009408 response to heat
GO:0016925 protein sumoylation
GO:0042026 protein refolding
Cellular Component
GO:0000794 condensed nuclear chromosome
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005940 septin ring
GO:0016020 membrane
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7zhs, PDBe:7zhs, PDBj:7zhs
PDBsum7zhs
PubMed37670029
UniProtO60884;
Q12306|SMT3_YEAST Ubiquitin-like protein SMT3 (Gene Name=SMT3)

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