Structure of PDB 7xhn Chain I Binding Site BS01

Receptor Information
>7xhn Chain I (length=517) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EEDALQMAVGYFEKGPIKASQNKDKTLEKHLKTVENVAWKNGLASEEIDI
LLNIALSGKFGNAVNTRILKCMIPATVISEDSVVKAVSWLCVGKCSGSTK
VLFYRWLVAMFDFIDRKEQINLLYGFFFASLQDDALCPYVCHLLYLLTKK
ENVKPFRVRKLLDLQAKMGMQPHLQALLSLYKFFAPALISVIYFKNSENL
WKTALLAVKQRNRGPSVLNNSLLLHYINCVRDEPVLLRFYYWLSQTLQEE
CIWYKVNNYEHGKEFTNFLDTIIRAECFLQEGFYSCEAFLYKSLPLWDGL
CCRSQFLQLVSWIPFSSFSEVKPLLFDHLAQLFFTSTIYFKCSVLQSLKE
LLQNWLLWLSMDIHMKLGGSMNSVSKLIHYVGWLSTTAMRLESNNTFLLH
FILDFYEKVCDIYINYNLPLVVLFPPGIFYSALLSLDTSILNQLCFIMHR
YRKNLTAAKKNENFSSKTYQEFNHYLTSMVGCLHPSFLSYAVSFKWSWYL
DYLFSQGLQGLKLFIRS
Ligand information
Receptor-Ligand Complex Structure
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PDB7xhn Structural insights into human CCAN complex assembled onto DNA.
Resolution3.71 Å
Binding residue
(original residue number in PDB)		S453 Y488 C491 S492 Q495 F560
Binding residue
(residue number reindexed from 1)		S304 Y339 C342 S343 Q346 F401
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005515 protein binding
Biological Process
GO:0000070 mitotic sister chromatid segregation
GO:0007059 chromosome segregation
GO:0007548 sex differentiation
GO:0034080 CENP-A containing chromatin assembly
GO:0034508 centromere complex assembly
Cellular Component
GO:0000775 chromosome, centromeric region
GO:0000776 kinetochore
GO:0000939 inner kinetochore
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0005829 cytosol
GO:0016604 nuclear body

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7xhn, PDBe:7xhn, PDBj:7xhn
PDBsum7xhn
PubMed36085283
UniProtQ92674|CENPI_HUMAN Centromere protein I (Gene Name=CENPI)

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