Structure of PDB 7u32 Chain I Binding Site BS01

Receptor Information
>7u32 Chain I (length=276) Species: 36374 (Visna/maedi virus EV1 KV1772) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
WIENIPLAEEEHNKWHQDAVSLHLEFGIPRTAAEDIVQQCDVCQENKMPS
TLRGSNKRGIDHWQVDYTHYEDKIILVWVETNSGLIYAERVKGETGQEFR
VQTMKWYAMFAPKSLQSDNGPAFVAESTQLLMKYLGIEHTTGIPWNPQSQ
ALVERTHQTLKNTLEKLIPMFNAFESALAGTLITLNIKRKGGLGTSPMDI
FIFNKEQQRIQQQSKSKQEKIRFCYYRTRKRGHPGEWQGPTQVLWGGDGA
IVVKDRGTDRYLVIANKDVKFIPPPK
Ligand information
Receptor-Ligand Complex Structure
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PDB7u32 Multivalent interactions essential for lentiviral integrase function.
Resolution3.46 Å
Binding residue
(original residue number in PDB)		R53 G54 S55 I143 Q148 S149 A151 R155
Binding residue
(residue number reindexed from 1)		R53 G54 S55 I143 Q148 S149 A151 R155
Enzymatic activity
Enzyme Commision number 2.7.7.-
2.7.7.49: RNA-directed DNA polymerase.
2.7.7.7: DNA-directed DNA polymerase.
3.1.-.-
3.1.13.2: exoribonuclease H.
3.1.26.4: ribonuclease H.
3.4.23.-
3.6.1.23: dUTP diphosphatase.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0008270 zinc ion binding
Biological Process
GO:0015074 DNA integration

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Molecular Function
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Biological Process
External links
PDB RCSB:7u32, PDBe:7u32, PDBj:7u32
PDBsum7u32
PubMed35504909
UniProtP35956|POL_VILVK Gag-Pol polyprotein (Gene Name=pol)

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