Structure of PDB 7of5 Chain I Binding Site BS01

Receptor Information

>7of5 Chain I (length=158) Species: 9606 (Homo sapiens)

SKAVTRHRRVMHFQRQKLMAVTEYIPPKPAIHPSCLPGLIRLLRREIAAV
FQDNRMIAVCQNVALSAEDKLLMRHQLRKHKILMKVFPNQVLKPFLEDSK
YQNLLPLFVGHNMLLVSEEPKVKEMVRILRTVPFLPLLGGCIDDTILSRQ
GFINYSKL

Ligand information

>7of5 Chain A (length=1389)

gcuaaaccuagccccaaaccccaccuuacuaccaaaccuuagccaaacca
uuuacauaaaguauaggcgauagaaauugauggcgcaauagauauaguac
cgcaagggaaagaugaaaaacaagcauaauauagcaaggacuaaccccua
uaccuucugcauaaugaauuaacuagaaauaacuuugcaaggagagccaa
agcuaagacccccgaaaccagacgagcuaccuaagaacagcuaaaagagc
acacccgucuauguagcaaaauagugggaagauuuauagguagaggcgac
aaaccuaccgagccuggugauagcugguuguccaagauagaaucuuaguu
caacuuuaaauuugcccacagaacccaaauccccuuguaaauuuaacugu
uaguccaaagaggaacagcucuuuggacacuaggaaaaaaccuuguagag
agaguaaaaaauuuaacacccauaguaggccuaaaagcagccaccaauua
agaaagcguucaagcucaacacaaaaaucccaaacauauaacugaacucc
ucacacccaauuggaccaaucuaucacccuauagaagaacuaauguuagu
auaaguaacaugaaaacauucuccuccgcauaagccugcgucagcugaca
auuaacagcccaauaucuacaaucaaccaacaagucauuauuacccucac
ugucaacccaacacaggcaugcucauaaggaaagguuaaaaaaaguaaaa
ggaacucggcaaaucuuaccccgccuguuuaccaaaaacaucaccucuag
caucaccaguauuagaggcaccgccuuccuuaaauagggauggcuccacg
aggguucagcugucucuuacuuuuaaccagugaaauugaccugcccguga
agaggcgggcauaacacagcaagacgagaagacccuauggagcuuuaauu
uauuaaugcaaacaccugcauuaaaaauuucgguuggggcgaccucggag
cagaacccaaccuccgagcaguacaugcuaagacuucaccagucaaagcg
aaccucaauugauccaauaacuugaccaacggaacaaguuacccuaggga
uaacagcgcaauccuauucuagaguccauaucaacaauaggguuuacgac
cucgauguuggaucaggacaucccgauggugcagccgcuauuaaagguuc
guuuguucaacgauuaaaguccuacgugaucugaguucagaccggaguaa
uccaggucgguuucuaucuacuuuaauuccucccuguacgaaaggacaag
agaaauaaggccuacuucacaaagcgccuucccccguaaaugauaucauc
ucaacuuaguauuauacccacacacccaagaacaggguu

<<<.......<<<<..............................<.....
.>...........<<.....>>.........>>.>>.............<
<....>>...............>>>...........<<<.......>>>.
..<.<........>.>.<<<<<<.........<<<.<<..<<....>>..
.>>.>>>...<<.<...<<<<.<.....<<<<<.<<<..<<<.....>>>
...<<<..<<<<........>>>>.>>>....>>>.>>>>>...<<....
...>>......>.>>>>......>.>>..<<<<<<....<<<<....>>>
><<<.<<<<<<<<<<.....<<.......>>.....>>>>>>>>>>..>>
>.<<<<<<<<<<......>>>>>>>>>>...<<<......>>>....<<<
.<<<...<..............<....<<<.........>>>....>...
....<<<......>>>..........................>...>>>>
>>........>>>>>>...<<<<<......>>>>>.........>>>>>>
.......<<..<<<....>>><<<<..<<<<........<<<<..>>>>.
.....<<<...<<<<.......................>>>>.......>
>>.....<<......>>.>>>>.....>>>>..<<<<...<<<<<<<<.<
<.........<......<<<<<<..<<<.........>>>...<<<<<<.
............>>>>>>....<<<.<<<<.....>>>>..>>>....>>
.>>>>.....>..>>.>>>>>>>>>>>>.>>...........<<<<<...
.....>>>>>.......<<..<<<.<<......<<<<.<<<<<<..<<<<
<.<<<<<<<<......>>>>>>>>>>>>>..<<<<.....>>>><<<<<<
...........>>>>>>..<<.....<<<..<<<<.....>>>>..>>>.
...>>.........<<<....>>>............>>>>..>>>>>>..
.....<<<..<.<<<<<<...<<.......>>...>>>>>>...>.>>.>
......<<<<<<.<<<<<<..<<.<<<<<<......>>>>>>...>>.<<
<<<.....>>>>>.....>>>>>..>...>>>.>>>...<<<<<<<....
>>>.>>>>....>>..>>>.>>...<<<.<<<.................>
>>.>>><<<<<...<<<....>>>.>>>>>......<<<...........
.....>>>...............<<<<.......>>>>.

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7of5 Structural basis of GTPase-mediated mitochondrial ribosome biogenesis and recycling.
• Resolution: 2.9 Å
• Binding residue (original residue number in PDB): S30 K31 V33 T34 R35 H41 K46 A106 V125 P127 N128
• Binding residue (residue number reindexed from 1): S1 K2 V4 T5 R6 H12 K17 A67 V86 P88 N89

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0005515 protein binding

Biological Process

• GO:0006412 translation
• GO:0032543 mitochondrial translation

Cellular Component

• GO:0005654 nucleoplasm
• GO:0005739 mitochondrion
• GO:0005743 mitochondrial inner membrane
• GO:0005762 mitochondrial large ribosomal subunit
• GO:0005840 ribosome
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:7of5, PDBe:7of5, PDBj:7of5
• PDBsum: 7of5
• PubMed: 34135319
• UniProt: Q7Z7H8|RM10_HUMAN Large ribosomal subunit protein uL10m (Gene Name=MRPL10)