Structure of PDB 7of2 Chain I Binding Site BS01

Receptor Information

>7of2 Chain I (length=158) Species: 9606 (Homo sapiens)

SKAVTRHRRVMHFQRQKLMAVTEYIPPKPAIHPSCLPGLIRLLRREIAAV
FQDNRMIAVCQNVALSAEDKLLMRHQLRKHKILMKVFPNQVLKPFLEDSK
YQNLLPLFVGHNMLLVSEEPKVKEMVRILRTVPFLPLLGGCIDDTILSRQ
GFINYSKL

Ligand information

>7of2 Chain A (length=1410)

gcuaaaccuagccccaaaccccaccuuacuaccagacaaccuuagccaaa
ccauuuacauaaaguauaggcgauagaaauugauggcgcaauagauauag
uaccgcaagggaaagaugaaaaaccaagcauaauauagcaaggacuaacc
ccuauaccuucugcauaaugaauuaacuagaaauaacuuugcaaggagag
ccaaagcuaagacccccgaaaccagacgagcuaccuaagaacagcuaaaa
gagcacacccgucuauguagcaaaauagugggaagauuuauagguagagg
cgacaaaccuaccgagccuggugauagcugguuguccaagauagaaucuu
aguucaacuuuaaauuugcccacagaacccucuaaauccccuuguaaauu
uaacuguuaguccaaagaggaacagcucuuuggacacuaggaaaaaaccu
uguagagagaguaaaaaauuuaacacccauaguaggccuaaaagcagcca
ccaauuaagaaagcguucaagcucaacacaaaaaucccaaacauauaacu
gaacuccucacacccaauuggaccaaucuaucacccuauagaagaacuaa
uguuaguauaaguaacaugaaaacauucuccuccgcauaagccugcguca
gauacugacaauuaacagcccaauaucuacaaucaaccaacaagucauua
uuacccucacugucaacccaacacaggcaugcucauaaggaaagguuaaa
aaaaguaaaaggaacucggcaaaucuuaccccgccuguuuaccaaaaaca
ucaccucuagcaucaccaguauuagaggcaccgccucacuuguuccuuaa
auagggaccuguauggcuccacgaggguucagcugucucuuacuuuuaac
cagugaaauugaccugcccgugaagaggcgggcauaacacagcaagacga
gaagacccuauggagcuuuaauuuauuaaugcaaacaccugcauuaaaaa
uuucgguuggggcgaccucggagcagaacccaaccuccgagcaguacaug
cuaagacuucaccagucaaagcgaaccucaauugauccaauaacuugacc
aacggaacaaguuacccuagggauaacagcgcaauccuauucuagagucc
auaucaacaauaggguuuacgaccucgauguuggaucaggacaucccgau
ggugcagccgcuauuaaagguucguuuguucaacgauuaaaguccuacgu
gaucugaguucagaccggaguaauccaggucgguuucuaucuacuuuaau
uccucccuguacgaaaggacaagagaaauaaggccuacuucacaaagcgc
cuucccccguaaaugauaucaucucaacuuaguauuauacccacacccaa
gaacaggguu

<<<.......<<<<.................................<..
....>...........<<.....>>.........>>.>>...........
..<<....>>................>>>...........<<<.......
>>>...<.<........>.>.<<<<<<.........<<<.<<..<<....
>>...>>.>>>...<<.<...<<<<.<.....<<<<<.<<<..<<<....
.>>>...<<<<.<<<<........>>>>>>>>....>>>.>>>>>...<<
.......>>......>.>>>>......>.>>..<<<<<<....<<<<...
.>>>><<<.<<<<<<<<<<.....<<..........>>.....>>>>>>>
>>>..>>>.<<<<<<<<<<......>>>>>>>>>>.<.<<<......>>>
.>..<<<.<<<...<..............<....<<<.........>>>.
...>.......<<<......>>>..........................>
...>>>>>>........>>>>>>...<<<<<......>>>>>........
.>>>>>><......<<..<<<....>>><<<<..<<<<........<<<<
<...>>>>>......<<<...<<<<.......................>>
>>.......>>>.....<<......>>.>>>>.....>>>>..<<<<...
<<<<<<<<.<<................<<<<<<..<<<.........>>>
...<<<<<<.............>>>>>>....<<<..<<..<<<<<<...
..>>>>>>..>>..>>>....>>.>>>>........>>.>>>>>>>>>>>
>.>>.....>.....<<<<<........>>>>>.......<<..<<<.<<
......<<<<.<<<<<<..<<<<<.<<<<<<<<......>>>>>>>>>>>
>>..<<<<.....>>>><<<<<<...........>>>>>>..<<.....<
<<..<<<<.....>>>>..>>>....>>.........<<<....>>>...
.........>>>>..>>>>>>.......<<<....<<<<<<...<<....
...>>...>>>>>>.....>>.>.......<<<<<..<<<<<..<<.<<<
<<<......>>>>>>...>>.<<<<<.....>>>>>.....>>>>>....
..>>>>.>....<<<<<<<....>>>.>>>>....>>..>>>.>>...<<
<.<<<.................>>>.>>><<<<<...<<<....>>>.>>
>>>......<<<................>>>.............<<<<..
.....>>>>.

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7of2 Structural basis of GTPase-mediated mitochondrial ribosome biogenesis and recycling.
• Resolution: 2.7 Å
• Binding residue (original residue number in PDB): S30 K31 V33 T34 R35 R38 H41 Q43 K46 A106 V125 P127 N128 G149 H150
• Binding residue (residue number reindexed from 1): S1 K2 V4 T5 R6 R9 H12 Q14 K17 A67 V86 P88 N89 G110 H111

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0005515 protein binding

Biological Process

• GO:0006412 translation
• GO:0032543 mitochondrial translation

Cellular Component

• GO:0005654 nucleoplasm
• GO:0005739 mitochondrion
• GO:0005743 mitochondrial inner membrane
• GO:0005762 mitochondrial large ribosomal subunit
• GO:0005840 ribosome
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:7of2, PDBe:7of2, PDBj:7of2
• PDBsum: 7of2
• PubMed: 34135319
• UniProt: Q7Z7H8|RM10_HUMAN Large ribosomal subunit protein uL10m (Gene Name=MRPL10)