Structure of PDB 7oba Chain I Binding Site BS01

Receptor Information
>7oba Chain I (length=105) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SSFQSDLDFCSDCGSVLPLPGAQDTVTCIRCGFNINVRDFEGKVVKTSVV
FHQLGECQGPVVDRRCPRCGHEGMAYHTRQMRSADEGQTVFYTCTNCKFQ
EKEDS
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain7oba Chain I Residue 201 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7oba Cryo-EM structures of human RNA polymerase I.
Resolution3.1 Å
Binding residue
(original residue number in PDB)		C20 C38
Binding residue
(residue number reindexed from 1)		C10 C28
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0001054 RNA polymerase I activity
GO:0003676 nucleic acid binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
Biological Process
GO:0006139 nucleobase-containing compound metabolic process
GO:0006351 DNA-templated transcription
GO:0006363 termination of RNA polymerase I transcription
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005736 RNA polymerase I complex

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Biological Process
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Cellular Component
External links
PDB RCSB:7oba, PDBe:7oba, PDBj:7oba
PDBsum7oba
PubMed34887565
UniProtQ9P1U0|RPA12_HUMAN DNA-directed RNA polymerase I subunit RPA12 (Gene Name=POLR1H)

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