Structure of PDB 7o9k Chain I Binding Site BS01

Receptor Information

>7o9k Chain I (length=212) Species: 9606 (Homo sapiens)

GSKAVTRHRRVMHFQRQKLMAVTEYIPPKPAIHPSCLPSPPSPPQEEIGL
IRLLRREIAAVFQDNRMIAVCQNVALSAEDKLLMRHQLRKHKILMKVFPN
QVLKPFLEDSKYQNLLPLFVGHNMLLVSEEPKVKEMVRILRTVPFLPLLG
GCIDDTILSRQGFINYSKLPSLPLVQGELVGGLTCLTAQTHSLLQHQPLQ
LTTLLDQYIREQ

Ligand information

>7o9k Chain A (length=1436)

gcuaaaccuagccccaaacccacuccaccuuacuaccacaaccuuagcca
aaccauuuacccaaauaaaguauaggcgauagaaauugggcgcaauagau
auaguaccgcaagggaaagaugaaaaaaccaagcauaauauagcaaggac
uaaccccuauaccuucugcauaaugaauuaacuagaaauaacuuugcaag
gagagccaaagcuaagacccccgaaaccagacgagcuaccuaagaacagc
uaaaagagcacacccgucuauguagcaaaauagugggaagauuuauaggu
agaggcgacaaaccuaccgagccuggugauagcugguuguccaagauaga
aucuuaguucaacuuuaaauuugcccacagaacccucuaaauccccuugu
aaauuuaacuguuaguccaaagaggaacagcucuuuggacacuaggaaaa
aaccuuguagagagaguaaaaaauuuaacccauaguaggccuaaaagcag
ccaccaauuaagaaagcguucaagcucaaaaaaaucccaaacauauaacu
gaacuccucacacccaauuggaccaaucuaucacccuauagaagaacuaa
uguuaguauaaguaacaugaaaacauucuccuccgcauaagccugcguca
gaucacugaacugacaauuaacagcccaauaucuacaaucaaccaacaag
ucauuauuacccucacugucaacccaacacaggcaugcucauaaggaaag
guuaaaaaaaguaaaaggaacucggcaaaucuuaccccgccuguuuacca
aaaacaucaccucuagcaucaccaguauuagaggcaccgccugcccagug
aucacuuguuccuuaaauagggaccuguaugaauggcuccacgaggguuc
agcugucucuuacuuuuaaccagugaaauugaccugcccgugaagaggcg
ggcauaacacagcaagacgagaagacccuauggagcuuuaauuuauuaau
gcaaacaccugcauuaaaaauuucgguuggggcgaccucggagcagaacc
caaccuccgagcaguacaugcuaagacuucaccagucaaagcgaaccuca
auugauccaauaacuugaccaacggaacaaguuacccuagggauaacagc
gcaauccuauucuagaguccauaucaacaauaggguuuacgaccucgaug
uuggaucaggacaucccgauggugcagccgcuauuaaagguucguuuguu
caacgauuaaaguccuacgugaucugaguucagaccggaguaauccaggu
cgguuucuaucuacuuucaaauuccucccuguacgaaaggacaagagaaa
uaaggccuacuucacaaagcgccuucccccguaaaugauaucaucucaac
uuaguauuauacccacacccacccaagaacaggguu

<<<.......<<<<...................................<
......>.........<.....<<.....>>....>..>>.>>.......
......<<....>>.................>>>...........<<<..
.....>>>...<.<<......>>.>.<<<<<<.........<<<.<<..<
<....>>...>>.>>>...<<.<...<<<<.<.....<<<<<.<<<..<<
<.....>>>...<<<..<<<<........>>>>.>>>....>>>.>>>>>
...<<.......>>......>.>>>>......>.>>..<<<<<<....<<
<<....>>>><<<.<<<<<<<<<<.....<<..........>>.....>>
>>>>>>>>..>>>.<<<<<<<<<<......>>>>>>>>>>...<<<....
..>>>....<<<.<<<...<............<....<<<.........>
>>....>.......<<<......>>>.......................>
...>>>>>>........>>>>>>...<<<<<......>>>>>........
.>>>>>><......<<..<<<....>>><<<<..<<<<........<<<<
<.........>>>>>......<<<...<<<<...................
....>>>>.......>>>.....<<......>>.>>>>.....>>>>..<
<<<...<<<<<<<<.<<.........<......<<<<<<..<<<......
...>>>...<<<<<<.............>>>>>>....<<<.....<<<<
..>>>>.<<<<<<.....>>>>>>..........>>>....>>.>>>>..
...>..>>.>>>>>>>>>>>>.>>.....>.....<<<<<........>>
>>>.......<<..<<<.<<.....<<<<<.<<<<<<..<<<<<.<<<<<
<<<......>>>>>>>>>>>>>..<<<<.....>>>><<<<<........
.....>>>>>..<<.....<<<..<<<<.....>>>>..>>>....>>..
.......<<<....>>>............>>>>..>>>>>>>.....<<<
<..<.<<<<<<...<<.......>>...>>>>>>...>.>>.>.>....<
<<<<<.<<<<<<..<<.<<<<<<......>>>>>>...>>.<<<<<....
.>>>>>.....>>>>>..>...>>>.>>>...<<<<<<<....>>>.>>>
>....>>..>>>.>>.....<<<.<<<.................>>>.>>
><<<<<...<<<....>>>.>>>>>......<<<................
>>>.................<<<<.......>>>>.

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7o9k Structural basis for late maturation steps of the human mitoribosomal large subunit.
• Resolution: 3.1 Å
• Binding residue (original residue number in PDB): G29 V33 T34 R35 R38 H41 K46 A106 K109 K124 V125 F126
• Binding residue (residue number reindexed from 1): G1 V5 T6 R7 R10 H13 K18 A78 K81 K96 V97 F98

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0005515 protein binding

Biological Process

• GO:0006412 translation
• GO:0032543 mitochondrial translation

Cellular Component

• GO:0005654 nucleoplasm
• GO:0005739 mitochondrion
• GO:0005743 mitochondrial inner membrane
• GO:0005762 mitochondrial large ribosomal subunit
• GO:0005840 ribosome
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:7o9k, PDBe:7o9k, PDBj:7o9k
• PDBsum: 7o9k
• PubMed: 34135318
• UniProt: Q7Z7H8|RM10_HUMAN Large ribosomal subunit protein uL10m (Gene Name=MRPL10)