Structure of PDB 7k3j Chain I Binding Site BS01

Receptor Information
>7k3j Chain I (length=85) Species: 7227 (Drosophila melanogaster) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KAVIKNADMSEEMQQDAVDCATQALEKYNIEKDIAAYIKKEFDKKYNPTW
HCIVGRNFGSYVTHETRHFIYFYLGQVAILLFKSG
Ligand information
>7k3j Chain B (length=25) Species: 7227 (Drosophila melanogaster) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
STLYKNAATQTERRTATRDAGTQVR
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7k3j Molecular principles of Piwi-mediated cotranscriptional silencing through the dimeric SFiNX complex.
Resolution2.5 Å
Binding residue
(original residue number in PDB)		K9 R60 N61 F62 G63 S64 Y65 V66 T67 H68 T70 F73 Y75 Y77 Q80
Binding residue
(residue number reindexed from 1)		K5 R56 N57 F58 G59 S60 Y61 V62 T63 H64 T66 F69 Y71 Y73 Q76
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003714 transcription corepressor activity
GO:0005515 protein binding
GO:0042803 protein homodimerization activity
GO:0045505 dynein intermediate chain binding
GO:0051959 dynein light intermediate chain binding
GO:0097718 disordered domain specific binding
Biological Process
GO:0000132 establishment of mitotic spindle orientation
GO:0007017 microtubule-based process
GO:0007283 spermatogenesis
GO:0007290 spermatid nucleus elongation
GO:0007291 sperm individualization
GO:0007476 imaginal disc-derived wing morphogenesis
GO:0008407 chaeta morphogenesis
GO:0022416 chaeta development
GO:0034454 microtubule anchoring at centrosome
GO:0035220 wing disc development
GO:0045892 negative regulation of DNA-templated transcription
GO:0048477 oogenesis
GO:0051017 actin filament bundle assembly
GO:0141006 piRNA-mediated retrotransposon silencing by heterochromatin formation
GO:1904801 positive regulation of neuron remodeling
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005814 centriole
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005868 cytoplasmic dynein complex
GO:0005874 microtubule
GO:0005875 microtubule associated complex
GO:0015630 microtubule cytoskeleton
GO:0030286 dynein complex
GO:0032991 protein-containing complex
GO:0090571 RNA polymerase II transcription repressor complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7k3j, PDBe:7k3j, PDBj:7k3j
PDBsum7k3j
PubMed33574069
UniProtQ24117|DYL1_DROME Dynein light chain 1, cytoplasmic (Gene Name=ctp)

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