Structure of PDB 7k36 Chain I Binding Site BS01

Receptor Information
>7k36 Chain I (length=599) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EFEYADTDKWAAELSELYSYTEGPEFLMNRKCFEEDFRIHVTDKKWTELD
TNQHRTHAMRLLDGLEVTAREKRLKVARAILYVAQGTSSEAEVQSWMRYN
IFLLLEVGTFNALVELLNMEIDNISLADSTDLRVLLNIMYLIVETVHQEC
EEWRTMRQTFRAELGSPLYNNEPFAIMLFGMVTKFCSGHAPHFPMKKVLL
LLWKTVLCTLGGFEELQSMKAEKRSILGLPPLPEDSIKVIRNMRAAGLPW
APKVREKDIEMFLESSRSKFIGYTLGSDTNTVVGLPRPIHESIKTLKQHK
YTSIAEVQAQMEEEYLRSPLSGGEEEVEQVPAETLYQGLLPSLPQYMIAL
LKILLAAAPTINILADVLPTVLQSMKLGVDVNRHKEVIVKAISAVLLLLL
KHFKLNHVYQFEYMAQHLVFANCIPLILKFFNQNIMSYITAKNSISQFCW
RNLFSCINLLRILNKLTKWKHSRTMMLVVFKSAPILKRALKVKQAMMQLY
VLKLLKVQTKYLGRQWRKSNMKTMSAIYQKVRHRLNDDWAYGNDWDFQAE
ECALRANIERFNARRYDRAHSNPDFLPVDNCLQSVLGFQMNYDLWLERE
Ligand information
Ligand IDIHP
InChIInChI=1S/C6H18O24P6/c7-31(8,9)25-1-2(26-32(10,11)12)4(28-34(16,17)18)6(30-36(22,23)24)5(29-35(19,20)21)3(1)27-33(13,14)15/h1-6H,(H2,7,8,9)(H2,10,11,12)(H2,13,14,15)(H2,16,17,18)(H2,19,20,21)(H2,22,23,24)/t1-,2-,3-,4+,5-,6-
InChIKeyIMQLKJBTEOYOSI-GPIVLXJGSA-N
SMILES
SoftwareSMILES
CACTVS 3.385O[P](O)(=O)O[CH]1[CH](O[P](O)(O)=O)[CH](O[P](O)(O)=O)[CH](O[P](O)(O)=O)[CH](O[P](O)(O)=O)[CH]1O[P](O)(O)=O
ACDLabs 12.01
OpenEye OEToolkits 2.0.7		C1(C(C(C(C(C1OP(=O)(O)O)OP(=O)(O)O)OP(=O)(O)O)OP(=O)(O)O)OP(=O)(O)O)OP(=O)(O)O
CACTVS 3.385O[P](O)(=O)O[C@@H]1[C@H](O[P](O)(O)=O)[C@H](O[P](O)(O)=O)[C@@H](O[P](O)(O)=O)[C@H](O[P](O)(O)=O)[C@H]1O[P](O)(O)=O
FormulaC6 H18 O24 P6
NameINOSITOL HEXAKISPHOSPHATE;
MYO-INOSITOL HEXAKISPHOSPHATE;
INOSITOL 1,2,3,4,5,6-HEXAKISPHOSPHATE
ChEMBLCHEMBL1233511
DrugBankDB14981
ZINCZINC000169289809
PDB chain7k36 Chain I Residue 901 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7k36 Cryo-EM structure of the Hippo signaling integrator human STRIPAK.
Resolution3.3 Å
Binding residue
(original residue number in PDB)		K308 K427 Y475 S477 K587 K590 K677 K680 Y712 K715 R744 R746
Binding residue
(residue number reindexed from 1)		K220 K253 Y301 S303 K401 K404 K465 K468 Y500 K503 R532 R534
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003674 molecular_function
GO:0005515 protein binding
GO:0019901 protein kinase binding
GO:0030674 protein-macromolecule adaptor activity
GO:0031267 small GTPase binding
Biological Process
GO:0007010 cytoskeleton organization
GO:0022604 regulation of cell morphogenesis
GO:0030866 cortical actin cytoskeleton organization
GO:0035331 negative regulation of hippo signaling
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0070062 extracellular exosome
GO:0090443 FAR/SIN/STRIPAK complex

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Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7k36, PDBe:7k36, PDBj:7k36
PDBsum7k36
PubMed33633399
UniProtQ5VSL9|STRP1_HUMAN Striatin-interacting protein 1 (Gene Name=STRIP1)

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