Structure of PDB 7a18 Chain I Binding Site BS01

Receptor Information

>7a18 Chain I (length=137) Species: 243230 (Deinococcus radiodurans R1 = ATCC 13939 = DSM 20539)

MKLHDLKPTPGSRKDRKRVGRGPGGTDKTAGRGHKGQKSRSGAGKGAFFE
GGRSRLIARLPKRGFNNVGTTYEVVKLSQLQDLEDTTFDRDTLEAYRLVR
RKNRPVKLLASGEISRAVTVHVDAASAAAIKAVEAAG

Ligand information

>7a18 Chain X (length=2699)

ggucaagauaguaaggguccacgguggaugcccuggcgcuggagccgaug
aaggacgcgauuaccugcgaaaagccccgacgagcuggagauacgcuuug
acucggggauguccgaauggggaaacccaccucguaagagguauccgcaa
ggaugggaacucagggaacugaaacaucucaguaccugaaggagaagaaa
gagaauucgauuccguuaguagcggcgagcgaacccggaucagcccaaac
cgaaacgcuugcguuucgggguuguaggaccaucaagccgaaguggcugg
aaagcuacaccucagaaggugagaguccuguaggcgaacgagcccugagu
aggucguuguucgugaaacgaugacugaauccgcgcggaccaccgcgcaa
ggcuaaauacucccagugaccgauagcgcauaguaccgugagggaaaggu
gaaaagaaccccgggaggggagugaaagagaaccugaaaccguggacuua
caagcagucauggcaccuuaugcguguuauggcgugccuauugaagcaug
agccggcgacuuagaccugacgugcgagcuuaaguugaaaaacggaggcg
gagcgaaagcgaguccgaauagggcggcauuaguacgucgggcuagacuc
gaaaccaggugagcuaagcaugaccagguugaaacccccgggggcggagg
accgaaccggugccugcugaaacagucucggaugaguuguguuuaggagu
gaaaagcuaaccgaaccuggagauagcuaguucuccccgaaauguauuga
gguacagccucggauguugaccauguccuguagagcacucacaaggcuaa
aaccuuaugaaacuccgaaggggcacgcguuuaguccgggagugaggcug
cgagagcuaacuuccguagccgagagggaaacaacccagaccaucagcua
aggucccuaaaugaucgcucagugguuaaggaugugucgucgcauagaca
gccaggagguuggcuuagaagcagccacccuucaaagagugcguaauagc
ucacuggucgagugacgaugcgccgaaaaugaucggggcucaagugaucu
accgaagcuauggauucaacucggaguugucugguaggggagcguucagu
ccgcggagaagccauaccggaaggagugguggagccgacugaagugcgga
ugccggcaugaguaacgauaaaagaagugagaaucuucuucgccguaagg
acaaggguuccuggggaagggucguccgcccagggaaagucgggaccuaa
ggugaggccgaacggcgcagccgauggacagcaggucaagauuccugcac
cgaucauguggagugauggagggacgcauuacgcuauccaaugccaagcu
auggcuaugcugguugguacgcucaagggcgaucgggucagaaaaucuac
cggucugccucagacguaucgggagccgaaguuggaaacgcgacggugcc
aagaaaagcuucuaaacguugaaacaugauugcccguaccgcaaaccgac
acagguguccgagugucaaugcacuaaggcgcgcgagagaacccucguua
aggaacuuugcaaucucaccccguaacuucggaagaagggguccccacgc
ugcguggggcgcagugaauaggcccaggcgacuguuuaccaaaaucacag
cacucugccaacacgaacaguggacguauagggugugacgccugcccggu
gccggaaggucaaguggagcggugcaagcugcgaaaugaagccccgguga
acggcggccuaagguagcgaaauuccuugucggguaaguuccgaccugca
cgaaaggcguaacgaucugggcgcugucucaacgagggacucggugaaau
ugaauuggcuguaaagaugcggccuacccguagcaggacgaaaagacccc
guggagcuuuacuauagucuggcauugggauucggguuucuagaaacuug
gauuucuaaccugaaaaaucacuuucggggaccgugcuuggcggguaguu
ugacuggggcggucgccucccaaaauguaacggaggcgcccaaaggucac
cucaagacgguuggaaaucgucuguagagcgcaaagguagaagguggcuu
gacugcgagacugacacgucgagcagggaggaaacucgggcuuagugaac
cggugguaccguguggaagggccaucgaucaacggauaaaaguuaccccg
gggauaacaggcugaucucccccgagaguccauaucggcggggagguuug
gcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaagg
guugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacguc
gugagacaguucggucucuauccgcuacgggcgcaggagaauugagggga
guugcuccuaguacgagaggaccggagugaacggaccgcuggucucccug
cugucguaccaacggcacaugcaggguagcuauguccggaacggauaacc
gcugaaagcaucuaagcgggaagccagccccaagaugaguucucccacug
aagguaagacucccggaagaccaccggguuaagaggccaggcgugcacgc
auagcaauguguucagcggacuggugcucaucagucgaggucuugacca

<<<<<<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<....
..<<<<<<<((..((>>>>.....<<<<<<...<<.))..))..>>....
..>>>>>>...>>>....<<<....>>><<<<......>>>><<<<....
>>>>>>...<<<<<<.....<......>......>>>>>.>.........
<<....>>...<<<<......<<.....>>.....>>>>...<<<....<
<<<<<<<....>>>>>>>>......<<<....<<..<<<...<<<<<...
...>>>>>((......<<<.....))>>>...>>>....>>..>>>....
.<<<<<<<<.........>>>>>>>>......<<<<<..((((>>>>>..
>>>......>>.>>>>>>.>>..............<<....>>....>>.
........<<<<....>>>>..................>>>>>>>>>>>.
......<<<<<<<<<<.......>>>>>>>>>>...<............>
.<<<<<<....<<<.<<<<<<<<<<..<<<...<<<....>>>...>>>.
..<<....>>...<<......>>.........>>>>>>>>>>>>>..<<.
<...<<<<<<.....<<<<<<<<<..<<<.....<<<<..>>>>......
>>>...<<<..<.<<........>>.>.>>>....>>>>>>>>>...<<<
.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<...
.>>>>><<<<<<<<<...<<<<.<<<<<<...<<<...<<<.<<<<....
..>>>>.>>>..>>.>...>>>>>>.>.>>>..>>>>>>>.>>..<<<<<
<<.<<......>>.>>>>>>>....<<<......>>>...<<<<.<<<..
.<<<(((.....<<<<<<...........<<..<<<<<<<<<........
<<<<<.<<.....<.........>.....>>..........<......>.
...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.
>>>...>>>>>>><..<<<<<...>>>>>..>....>>>>>><.<<<<<<
<.<<......<<<<<.<<....>>.>>>>>...>>.>>>>>>>..>....
.>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<
<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...
<<<...<<<<..>>>>...>>>...>>...<<<<<........>>>>>))
<<<<<<<<<...<<...<<<<....<<<<..<<<..<<<<<.<<<<.<<.
..[[....>>>>>><<<<<<<.<<..<<<<<<<<<<...<<.....>>.>
>>>>>.>>>>..>>>>>>>>>..........>>>>>...>>>...>>>>.
........>>>>...>>......>>>>>>>>>>>>>..>>.....<<...
...>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.
<<...............<<<<<....<....>.....>>>>><<<<<<<<
.>>>>>>>>............<<<<<<<<<..<<...........>>..<
<<<<<<.....<<<.....>>>.......>>>>>>>.<<<<<.<<<..<<
<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..
>>>>>...........<...........<<<<<<.....>>>>>>.....
>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....
>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<
<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<..<<<......>>>..>
>>>>>>...<<<<<<.......>>.>>>>....>>>>>.>>>..>>>>>.
.<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<
<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>.
..<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......
<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>
>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>
>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>
>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<
....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<.
.<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<
<<<<<<<.]].>>>>>>...>>>>>...>>>>.>>>>>....<<....<<
<<<...........>>>>>....>>..>>>>.......>>>>>>>..<<.
.>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<
<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>>>>>>.

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7a18 Ribosome-binding and anti-microbial studies of the mycinamicins, 16-membered macrolide antibiotics from Micromonospora griseorubida.
• Resolution: 3.4 Å
• Binding residue (original residue number in PDB): L3 H4 L6 P8 T9 G11 S12 R13 K14 D15 R16 K17 R18 V19 G20 R21 G22 P23 G24 D27 K28 T29 A30 G31 R32 G33 K35 G36 Q37 K38 S39 R40 S41 A47 F49 E50 R53 S54 R55 L56 I57 A58 R59 L60 K62 R63 F65 N67 L93 K102 N103 T119 V120
• Binding residue (residue number reindexed from 1): L3 H4 L6 P8 T9 G11 S12 R13 K14 D15 R16 K17 R18 V19 G20 R21 G22 P23 G24 D27 K28 T29 A30 G31 R32 G33 K35 G36 Q37 K38 S39 R40 S41 A47 F49 E50 R53 S54 R55 L56 I57 A58 R59 L60 K62 R63 F65 N67 L93 K102 N103 T119 V120

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0006412 translation

Cellular Component

• GO:0005840 ribosome
• GO:0015934 large ribosomal subunit

External links

• PDB: RCSB:7a18, PDBe:7a18, PDBj:7a18
• PDBsum: 7a18
• PubMed: 34417608
• UniProt: Q9RSK9|RL15_DEIRA Large ribosomal subunit protein uL15 (Gene Name=rplO)